Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration

Wang, Fuxiao; Gu, Zhengrong; Yin, Zhifeng; Zhang, Wencai; Bai, Long; Su, Jiacan

doi:10.1186/s12951-023-02003-0

Cited by 8 publications

(2 citation statements)

References 199 publications

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“…Fine-tuning of the biomineralization parameters led to the controlled incorporation of hydroxyapatite onto native spider silk, maintaining good mechanical properties [138]. Natural bio-based nanomaterials can provide outstanding scaffold properties for bone tissue engineering [139] and cartilage regeneration [9,10]. The results showed that mineralized silk still has a performance comparable to many natural and artificial fibers [138].…”

Section: Bone and Cartilage Tissue Repairmentioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.

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Section: Bone and Cartilage Tissue Repairmentioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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show abstract

“…To improve drug absorption and enrichment, a variety of nanocarriers have been employed recently, including nanoparticles, nanofiber, nanosheets, and nanoemulsions. − Among them, nanoemulsion (NE) is a promising nanocarrier system with good stability and skin penetration, with a particle size between 10 and 100 nm . A nanoemulsion system has been developed not only to enhance percutaneous absorption but also to allow the drug to target the skin or even its substructure, which has been widely used in the loading of insoluble drugs and Chinese herbal extracts in recent years. − However, the low viscosity of NE makes it difficult to apply it to the skin.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Compound Salvia miltiorrhiza–Blumea balsamifera Nanoemulsion Gel and Its Effect on Hypertrophic Scars in the Rabbit Ear Model

Chen,

Wang,

Gong

et al. 2024

Mol. Pharmaceutics

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Hypertrophic scars (HS) still remain an urgent challenge in the medical community. Traditional Chinese medicine (TCM) has unique advantages in the treatment of HS. However, due to the natural barrier of the skin, it is difficult for the natural active components of TCM to more effectively penetrate the skin and exert therapeutic effects. Therefore, the development of an efficient drug delivery system to facilitate enhanced transdermal absorption of TCM becomes imperative for its clinical application. In this study, we designed a compound Salvia miltiorrhiza−Blumea balsamifera nanoemulsion gel (CSB-NEG) and investigated its therapeutic effects on rabbit HS models. The prescription of CSB-NEG was optimized by single-factor, pseudoternary phase diagram, and central composite design experiments. The results showed that the average particle size and PDI of the optimized CSB-NE were 46.0 ± 0.2 nm and 0.222 ± 0.004, respectively, and the encapsulation efficiency of total phenolic acid was 93.37 ± 2.56%. CSB-NEG demonstrated excellent stability and skin permeation in vitro and displayed a significantly enhanced ability to inhibit scar formation compared to the CSB physical mixture in vivo. After 3 weeks of CSB-NEG treatment, the scar appeared to be flat, pink, and flexible. Furthermore, this treatment also resulted in a decrease in the levels of the collagen I/III ratio and TGF-β 1 and Smad2 proteins while simultaneously promoting the growth and remodeling of microvessels. These findings suggest that CSB-NEG has the potential to effectively address the barrier properties of the skin and provide therapeutic benefits for HS, offering a new perspective for the prevention and treatment of HS.

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Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium

Gong,

Tang,

Dai

et al. 2024

Advanced NanoBiomed Research

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Osteoarthritis (OA) is characterized mainly by articular cartilage loss, subchondral osteosclerosis, and chronic inflammation and involves multiple types of cellular dysfunction and tissue lesions. The rapid development of nanotechnology and materials science has contributed to the application of biomimetic nanomaterials in the biomedical field. By optimizing the composition, hardness, porosity, and drug loading of biomimetic nanomaterials, their unique physicochemical properties drive potential applications in bone repair. This article reviews the present understanding of the physiopathological mechanism and clinical treatment drawbacks of OA and summarizes various types of biomimetic nanomaterials for OA that target lesion sites, such as cartilage, subchondral bone, and synovium, through simulation of the physiological structure and microenvironment. Eventually, the challenges and prospects for the clinical translation of biomimetic nanomaterials are further discussed, with the goal of accessing an effective approach for OA treatment.

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Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration

Cited by 8 publications

References 199 publications

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Preparation of Compound Salvia miltiorrhiza–Blumea balsamifera Nanoemulsion Gel and Its Effect on Hypertrophic Scars in the Rabbit Ear Model

Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium

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