2008
DOI: 10.1016/j.bone.2008.01.013
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Cell viability, osteoblast differentiation, and gene expression are altered in human osteoblasts from hypertrophic fracture non-unions

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Cited by 58 publications
(45 citation statements)
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“…Osteoblasts taken from human patients with fracture nonunion had anomalous expression of 281 genes, including sets of genes that regulate growth factor activity, osteogenesis, angiogenesis, cytokine activity, and the inflammatory response. 21 Similar results were seen in an animal model of delayed osseous union; at several timepoints after bone injury, the tissue from the nonunion site had reduced expression of several growth factors, including BMP-2, BMP-4, BMP-7, and TGF-b1, as well as the cytokine TNF-a. 22 These findings underscore the importance of regulated acute inflammatory signaling in priming bone regeneration.…”
Section: Aberrant Inflammation Results In Bone Damagesupporting
confidence: 63%
“…Osteoblasts taken from human patients with fracture nonunion had anomalous expression of 281 genes, including sets of genes that regulate growth factor activity, osteogenesis, angiogenesis, cytokine activity, and the inflammatory response. 21 Similar results were seen in an animal model of delayed osseous union; at several timepoints after bone injury, the tissue from the nonunion site had reduced expression of several growth factors, including BMP-2, BMP-4, BMP-7, and TGF-b1, as well as the cytokine TNF-a. 22 These findings underscore the importance of regulated acute inflammatory signaling in priming bone regeneration.…”
Section: Aberrant Inflammation Results In Bone Damagesupporting
confidence: 63%
“…Critical bone defects and fracture non-union remain major challenges in current clinical practice (Hofmann et al 2008;Zong et al 2010). From a patient's perspective, the ultimate goal is replacement of their damaged/lost bone with autogenous material, harvested with minimal donor side morbidity.…”
Section: Introductionmentioning
confidence: 99%
“…The gene expression of BMP antagonists (noggin and follistatin) and certain MMPs, MMP-7 and MMP-12 are higher in non-union tissues compared to that in normal healing callus (196). In contrast, many genes are inhibited in non-union including growth factors IGF-2, FGF-1, TGF-β, PDGF, Wnt-induced proteins, B-catenin as well as receptors for PGE2 (197).…”
Section: Cytokinesmentioning
confidence: 99%