2016
DOI: 10.3389/fmicb.2016.00165
|View full text |Cite
|
Sign up to set email alerts
|

Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis

Abstract: Campylobacter jejuni is the most frequent cause of human food-borne gastroenteritis and chicken meat is the main source of infection. Recent studies showed that broiler chicken immunization against Campylobacter should be the most efficient way to lower the number of human infections by this pathogen. Induction of the mucosal immune system after oral antigen administration should provide protective immunity to chickens. In this work we tested the usefulness of Lactococcus lactis, the most extensively studied l… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
21
0
3

Year Published

2016
2016
2019
2019

Publication Types

Select...
7
2

Relationship

2
7

Authors

Journals

citations
Cited by 27 publications
(24 citation statements)
references
References 110 publications
(131 reference statements)
0
21
0
3
Order By: Relevance
“…This demonstrated the stability and immunogenicity of surface anchored proteins as per many previous studies. Other lactococcal based vaccines developed or under development for the poultry industry include those against H1N1 [111], H5N2 [112], avian infectious bronchitis virus [113] and infections by Campylobacter jejuni [114]. …”
Section: Lactococcus Lactis As a Cell Factorymentioning
confidence: 99%
“…This demonstrated the stability and immunogenicity of surface anchored proteins as per many previous studies. Other lactococcal based vaccines developed or under development for the poultry industry include those against H1N1 [111], H5N2 [112], avian infectious bronchitis virus [113] and infections by Campylobacter jejuni [114]. …”
Section: Lactococcus Lactis As a Cell Factorymentioning
confidence: 99%
“…We have shown that in ovo chicken immunization with liposomes containing Campylobacter hybrid protein rCjaAD results in a moderate protection against colonization (Kobierecka, Wyszynska, et al., ). The same hybrid protein expressed on the surface of L. lactis also exerted a moderately positive effect, when used for chicken vaccination (Kobierecka, Olech, et al., ). We postulate that the efficacy of in ovo immunization with nonliving carriers may be increased by a boost and immunization after hatching with live vectors carrying Campylobacter antigens known to induce a mucosal immune response.…”
Section: Discussionmentioning
confidence: 99%
“…Jak dotąd, spośród przedstawicieli bakterii z grupy LAB, jako nośnik antygenów Campylobacter wykorzystano szczep Lactococcus lactis. Szczep L. lactis prezentujący na powierzchni rCjaAD wykazywał wyższy efekt ochronny niż szczep L. lactis wytwarzający białko zlokalizowane w cytoplazmie oraz od szczepu L. lactis prezentującego na powierzchni CjaA, jednak różnice te nie były istotne statystycznie; poziom kolonizacji obniżył się jedynie o 1 rząd wielkości [46]. W roli nośników antygenów Campylobacter testowano także cząstki GEM (Gram-positive Enhancer Matrix) uzyskane z komórek L. salivarius.…”
Section: Wybór Nośnikaunclassified