Cell wall distraction and biofilm inhibition of marine Streptomyces derived angucycline in methicillin resistant Staphylococcus aureus

Mary, Thankaraj Rajam Jabila; Kannan, Rajaretinam Rajesh; Iniyan, Appadurai Muthamil; Ramachandran, D.; Vincent, Samuel Gnana Prakash

doi:10.1016/j.micpath.2020.104712

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…Studies have shown that some symbiotic microorganisms are species-specific [8], indicating that marine animals may be rich in microbial resources. And the active substances in marine animals are mostly produced by their associated microorganisms, of which actinomycetes are an important group [5][6][7]. Therefore, actinomycetes associated with marine animals are a flourishing source for novel natural products.…”

Section: Chemical Structures and Biological Properties Of The Actinomycetes Associatedmentioning

confidence: 99%

“…Compared with actinomycetes isolated from seawater and sediment samples, recent reports of secondary metabolites from marine actinomycetes associated with a variety of aquatic organisms, including invertebrates such as sponges, corals, ascidians, echinoderms, and vertebrates such as pufferfish, as well as algae and seaweed, have increased significantly [4]. Studies have indicated that multiple active compounds previously isolated from marine invertebrates were possibly produced by their symbiotic microorganisms, especially actinomycetes [5][6][7]. With interactions of the host and having special ecological status, the actinomycetes associated with marine organisms have more potential to produce active metabolites acting as chemical defenses to protect the host from predators and microbial infection.…”

Section: Introductionmentioning

confidence: 99%

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Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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Section: Chemical Structures and Biological Properties Of The Actinomycetes Associatedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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“…In recent years, there have been various bioactive compounds with anti-staphylococcal and anti-MRSA biofilms activity in a wide variety of chemotypes, reported from drug discovery studies investigating the biosynthetic potentials of Streptomyces bacteria. Several bioactive compounds, isolated from Streptomyces sp., were shown to exhibit promising antibiofilm activities that prevent biofilm formation and disrupt the preformed biofilms of S. aureus and MRSA at the micromolar range, including alnumycin D (1), granaticin B (2), kalafungin (3), medermycin (4) [63], AT37-1 (5) [64], collismycin C (6), napyradiomycin SF2415B3 ( 7) [65], hygrocin C ( 8) [66], 8-O-metyltetrangomycin (10) [67], antibiotic 5812-A/C [68], panglimycin D (11) [69] and streptorubin B ( 14) [70] (Table 1). The chemical structures of these compounds are illustrated in Figure 1.…”

Section: Newly Reported Anti-mrsa Biofilm Compounds Synthesized By Streptomyces Bacteriamentioning

confidence: 99%

Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices

Pusparajah

Letchumanan

Law

et al. 2021

IJMS

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Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent causes of biomedical device-related infection, which are difficult to treat and are often persistent and recurrent. Thus, new and effective antibiofilm agents are urgently needed. In this article, we review the most relevant literature of the recent years reporting on promising anti-MRSA biofilm agents derived from the genus Streptomyces bacteria, and discuss the potential contribution of these newly reported antibiofilm compounds to the current strategies in preventing biofilm formation and eradicating pre-existing biofilms of the clinically important pathogen MRSA. Many efforts are evidenced to address biofilm-related infections, and some novel strategies have been developed and demonstrated encouraging results in preclinical studies. Nevertheless, more in vivo studies with appropriate biofilm models and well-designed multicenter clinical trials are needed to assess the prospects of these strategies.

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“…They can also damage the cell membrane's ability to balance nutrients and ions, reducing the cell's survival ability. 8,9 Certain Streptomycetes metabolites can disrupt critical fatty acid production, disrupting the cell membrane and reducing the organism's survival. 10 First, ribosomal functional areas were blocked, which halted protein synthesis in bacteria.…”

Section: Introductionmentioning

confidence: 99%

Streptomyces tetracycline’s computational behavior against polyketide synthase of aflatoxigenic fungi

Kumari,

Jyoti,

Kumar

et al. 2023

IJMMTD

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produces a variety of bioactive compounds that prevent fungal growth, including aflatoxins. Aflatoxigenic fungi ( and ) are being researched concerning spp. and can prevent the spread of aflatoxins-producing fungi. Aflatoxin-degrading enzymes, which can convert poisonous aflatoxins into less dangerous compounds, are also produced by spp. The processes through which these microorganisms can be used to reduce aflatoxins in food and agricultural systems are still the subject of active research. To evaluate the novelty of tetracycline against the biosynthesis of aflatoxin in aflatoxigenic fungi via computational approach. In this study, we performed molecular docking of polyketide synthase (Pks-A), an enzyme that initiates aflatoxin biosynthesis using tetracycline, using the online SeamDock server. Our results showed that tetracycline had a strong affinity for Pks-A in the binding pocket. The binding energy of tetracycline was -12.7 kcal/mol, indicating a strong binding affinity between the two molecules. Furthermore, the binding site was located in the active site, which is a conserved region in Pks-A and is essential for catalysing the formation of aflatoxin. The results of our docking study suggest that tetracycline may be an effective inhibitor of aflatoxin biosynthesis.

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Cell wall distraction and biofilm inhibition of marine Streptomyces derived angucycline in methicillin resistant Staphylococcus aureus

Cited by 10 publications

References 37 publications

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products from Actinomycetes Associated with Marine Organisms

Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices

Streptomyces tetracycline’s computational behavior against polyketide synthase of aflatoxigenic fungi

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