Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss

Eugenis, Ioannis; Wu, Di; Rando, Thomas A.

doi:10.1016/j.biomaterials.2021.121173

Cited by 54 publications

(31 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The soft nature at body temperature gave PGD the advantages of matching the mechanical properties of soft tissue; the tough plasticity at room temperature provided it strength for surgical delivery. Unique characteristics made PGD suitable for fabricating intelligent deformable implants for medical devices, tissue engineering, drug delivery, and so forth. , The in vivo degradation of the implants is important to match tissue regeneration time, maintain mechanical support, and control drug release kinetics; these phenomena correlate with the biomedical transformation of burgeoning polymers, such as PGD . In this study, we regulated enzyme activity by adjusting the acidity of PGD degradation products to achieve an adjustable in vivo degradation rate.…”

Section: Discussionmentioning

confidence: 99%

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

et al. 2023

View full text Add to dashboard Cite

Poly(glycerol-dodecanoate) (PGD) has garnered increasing attention in biomedical engineering for its degradability, shape memory, and rubber-like mechanical properties. Adjustable degradation is important for biodegradable implants and is affected by various aspects, including material properties, mechanical environments, temperature, pH, and enzyme catalysis. The crosslinking and chain length characteristics of poly(lactic acid) and poly(caprolactone) have been widely used to adjust the in vivo degradation rate. The PGD degradation rate is affected by its crosslink density in in vitro hydrolysis; however, there is no difference in vivo. We believe that this phenomenon is caused by the differences in enzymatic conditions in vitro and in vivo. In this study, it is found that the degradation products of PGD with different molar ratios of hydroxyl and carboxyl (MRH/C) exhibit varied pH values, affecting the enzyme activity and thus achieving different degradation rates. The in vivo degradation of PGD is characterized by surface erosion, and its mass decreases linearly with degradation duration. The degradation duration of PGD is linearly extrapolated from 9–18 weeks when MRH/C is in the range of 2.00–0.75, providing a protocol for adjusting the degradation durations of subsequent implants made by PGD.

show abstract

Section: Discussionmentioning

confidence: 99%

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Currently, surgical reconstruction is the most widely used treatment for severe muscle tissue injury. Unfortunately, this treatment approach has serious deficiencies in donor shortages, low survival rates, and complications in the supply area [ 93 ]. Therefore, muscle tissue engineering has become one of the most practical therapeutic strategies for muscle repair.…”

Section: Applications Of Gbns In Soft Tissue Engineeringmentioning

confidence: 99%

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Chen

Weng

2022

Materials

View full text Add to dashboard Cite

Over the last few decades, tissue engineering has become an important technology for repairing and rebuilding damaged tissues and organs. The scaffold plays an important role and has become a hot pot in the field of tissue engineering. It has sufficient mechanical and biochemical properties and simulates the structure and function of natural tissue to promote the growth of cells inward. Therefore, graphene-based nanomaterials (GBNs), such as graphene and graphene oxide (GO), have attracted wide attention in the field of biomedical tissue engineering because of their unique structure, large specific surface area, good photo-thermal effect, pH response and broad-spectrum antibacterial properties. In this review, the structure and properties of typical GBNs are summarized, the progress made in the development of GBNs in soft tissue engineering (including skin, muscle, nerve and blood vessel) are highlighted, the challenges and prospects of the application of GBNs in soft tissue engineering have prospected.

show abstract

“…Skeletal muscle has a robust ability to regenerate form and function; however, this endogenous process is impaired in rare conditions, such as following complex high-energy orthopaedic traumas ( Greising et al, 2020 ; Eugenis et al, 2021 ). Volumetric muscle loss (VML) injuries occur following the abrupt and irrecoverable loss of muscle due to trauma or surgical ablation, resulting in irreversible functional impairments ( Grogan et al, 2011 ), and represent a condition whereby the endogenous regenerative capacity of muscle is lost.…”

Section: Introductionmentioning

confidence: 99%

Human muscle in gene edited pigs for treatment of volumetric muscle loss

et al. 2022

View full text Add to dashboard Cite

Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.

show abstract

Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss

Cited by 54 publications

References 186 publications

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Human muscle in gene edited pigs for treatment of volumetric muscle loss

Contact Info

Product

Resources

About