Cells to shells: The genomics of mollusc exoskeletons

Clark, Melody S.; Power, Deborah M.; Sundell, Kristina

doi:10.1016/j.margen.2016.04.011

Cited by 1 publication

(1 citation statement)

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“…The de novo transcriptome of a non-model organism was first published only eight years ago55 and since then, rapidly emerging sequence technologies have been increasingly applied to the field of biomineralisation14565758. A considerable amount of the work on the molecular control of shell production represents the collection and description of much-needed sequence data and initial characterisations of gene and protein expression patterns.…”

Section: Discussionmentioning

confidence: 99%

An Antarctic molluscan biomineralisation tool-kit

Sleight

Marie

Jackson

et al. 2016

Sci Rep

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The Antarctic clam Laternula elliptica lives almost permanently below 0 °C and therefore is a valuable and tractable model to study the mechanisms of biomineralisation in cold water. The present study employed a multidisciplinary approach using histology, immunohistochemistry, electron microscopy, proteomics and gene expression to investigate this process. Thirty seven proteins were identified via proteomic extraction of the nacreous shell layer, including two not previously found in nacre; a novel T-rich Mucin-like protein and a Zinc-dependent metalloprotease. In situ hybridisation of seven candidate biomineralisation genes revealed discrete spatial expression patterns within the mantle tissue, hinting at modular organisation, which is also observed in the mantle tissues of other molluscs. All seven of these biomineralisation candidates displayed evidence of multifunctionality and strong association with vesicles, which are potentially involved in shell secretion in this species.

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