1995
DOI: 10.1006/excr.1995.1158
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Cellular Aging and Transformation Suppression: A Role for Retinoic Acid Receptor β2

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Cited by 28 publications
(13 citation statements)
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“…In contrast, we could not detect any RNA for RXR␤ and RXR␥, while that for RAR␤ was strongly induced from barely detectable levels in untreated fibroblasts to high levels in the presence of 9C-RA or t-RA. Similar observations have been made in human dermal (60) and lung (61) fibroblasts.…”
Section: Stromelysin-3 Gene Induction By Retinoidssupporting
confidence: 86%
“…In contrast, we could not detect any RNA for RXR␤ and RXR␥, while that for RAR␤ was strongly induced from barely detectable levels in untreated fibroblasts to high levels in the presence of 9C-RA or t-RA. Similar observations have been made in human dermal (60) and lung (61) fibroblasts.…”
Section: Stromelysin-3 Gene Induction By Retinoidssupporting
confidence: 86%
“…In particular, RARb2 isoform is upregulated in senescent dermal fibroblasts [Lee et al, 1995] and mammary epithelial cells [Swisshelm et al, 1994], suggesting a role for RARb in replicative senescence. Expression of RARb not only sensitizes cells to retinoids but also has its own growth-inhibitory effect [Si et al, 1996].…”
Section: Nature Of Senescence-associated Retinoid-inducible Growth Inmentioning
confidence: 99%
“…A growing body of evidence supports the hypothesis that RAR-b2 is a tumor suppressor gene [14,15,22]. A functional study [16] demonstrated that RAR-b2, like the tumor suppressor gene p53, can inhibit oncogene-induced focus formation. RAR-b2 has also been shown to be expressed in normal, senescing mammary epithelial cells and repressed in malignant cell lines [10].…”
Section: Discussionmentioning
confidence: 93%
“…This hypothesis has been supported by the observation that introduction of RAR-b2 protein into RA-insensitive breast cancer cell lines restored RA responsiveness [15]. Furthermore, RAR-b2 has been shown to function as a tumor suppressor gene in epidermoid lung carcinoma cells [14] and in gynecologic cancer cells [16].…”
Section: Introductionmentioning
confidence: 95%