Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging

Abstract

Research suggests that polyphenolic compounds contained in fruits and vegetables that are rich in color may have potent antioxidant and anti-inflammatory activities. The present studies determined if stilbene (e.g., resveratrol) compounds would be efficacious in reversing the deleterious effects of aging in 19 month old Fischer 344 rats. Experiment I utilized resveratrol and six resveratrol analogues and examined their efficacies in preventing dopamine-induced decrements in calcium clearance following oxotremorine-induced depolarization in COS-7 cells transfected with M1 muscarinic receptors (MAChR) that we have shown previously to be sensitive to oxidative stressors. Experiment II utilized the most efficacious analogue (pterostilbene) from experiment I and fed aged rats a diet with a low (0.004%) or a high (0.016%) concentration of pterostilbene. Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus.

Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

“…The structure of the product 5 was identified by direct comparison of its NMR spectra with the reported data. 28) Thus, compound 5 was determined to be pterostilbene 4′-β-glucopyranoside (glucoside).…”

Protective effects of berry polyphenols against age-related cognitive impairment

“…Unfortunately, there are no reported estimates regarding pterostilbene intake in humans. Joseph et al [179] have reported that dietary pterostilbene is effective in reversing cognitive deficits in aged rats with a correlation with hippocampal pterostilbene levels. Quite recently, it has been shown that, at equivalent and diet-achievable doses, pterostilbene is a more potent modulator of cognition and cellular stress than resveratrol, likely driven by increased peroxisome proliferator-activated receptor alpha (PPAR-␣) expression and the aforementioned methoxy moiety [180].…”

Determination of pterostilbene in rat plasma by a simple HPLC‐UV method and its application in pre‐clinical pharmacokinetic study

“…Furthermore, its anti-metastatic efficacy was demonstrated in a mouse model with highly malignant B16 F10 melanoma cells (Ferrer et al, 2005). Besides anti-cancer effects, other resveratrol-like activities, including analgesia (Remsberg et al, 2008), anti-ageing (Joseph et al, 2008), anti-diabetic (Amarnath Manickam et al, 1997;Pari and Satheesh, 2006), anti-inflammation (Hougee et al, 2005;Pan et al, 2008a) (Remsberg et al, 2008), anti-obesity (Rimando et al, 2005), anti-oxidation (Amarnath Kim et al, 2009;Perecko et al, 2008;Remsberg et al, 2008;Rimando et al, 2002) and neuro-protection (Joseph et al, 2008;Meng et al, 2008;Pan et al, 2008a), have also been reported.…”