Cellular and Biochemical Responses to GABAB Receptor Activation

Cunningham, M D; Enna, S.J.

doi:10.1007/978-1-4757-2597-1_8

Cited by 3 publications

(1 citation statement)

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“…Blockade of this effect by either a GABA A or GABA B antagonist suggests that interactions may occur between GABA A and GABA B receptors. GABA B receptors are thought to alter neuronal excitation and regulate release of other neurotransmitters (see Cunningham and Enna 1997). Thus, changes in the function of GABA B receptors by ethanol could result in substantial perturbation of neuronal activity.…”

Section: Julie Broadbent · Wendy E Harlessmentioning

confidence: 99%

Differential effects of GABA A and GABA B agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice

Broadbent

Harless

1999

Psychopharmacology

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Contemporary theories of drug abuse suggest that behavioral sensitization plays an important role in addiction. However, few studies have examined the mechanisms underlying behavioral sensitization to ethanol. The present study examined the ability of THIP (2, 4, or 8 mg/kg) and baclofen (5.0, 6.25, or 7.5 mg/kg), GABA(A) and GABA(B) agonists, respectively, to prevent development of sensitization to the locomotor stimulant effects of ethanol (2 g/kg) in DBA/2 J mice. Ethanol was administered immediately before four 5-min activity trials conducted at 48-h intervals. Administration of ethanol on each of the four trials resulted in behavioral sensitization in control groups. While having few effects on activity when given alone, both GABA agonists completely blocked the acute stimulant response to ethanol on the first trial. Administration of THIP prior to ethanol on each trial failed to prevent development of sensitization. In contrast, all doses of baclofen blocked sensitization. Assessment of blood ethanol levels 15, 50 and 100 min after administration of ethanol indicated that baclofen did not change the pharmacokinetics of ethanol. These results indicate an important role for GABA(B) receptors, but not GABA(A) receptors, in development of sensitization to the locomotor stimulant effects of ethanol.

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Section: Julie Broadbent · Wendy E Harlessmentioning

confidence: 99%