Cellular and functional actions of tofacitinib related to the pathophysiology of hibernoma development

Radi, Smaail; Vogel, Werner; Bartholomew, Phillip M.; Koza-Taylor, Petra; Παπανικολάου, Αλέξανδρος; Wisialowski, Todd; Nambiar, Prashant R.; Ball, Douglas J.

doi:10.1016/j.yrtph.2017.10.020

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Interestingly, in a 2-year carcinogenicity study with tofacitinib (an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis), an increased incidence of hibernoma was noted in female rats. In this research, it was hypothesized that Janus kinase/Signal Transducer and Activator of Transcription inhibition in BAT along with sympathetic stimulation might contribute to the genesis of hibernomas ( 31 ). Both investigations call into question the simplicity of these neoplasms and highlight the possible metabolic complexity of hibernomas.…”

Section: Discussionmentioning

confidence: 99%

Nipple Hibernoma in a Dog: A Case Report With Literature Review

et al. 2021

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This report provides a clinical, histological, and immunohistochemical description of an unusual hibernoma (pale cell variant) in the subepidermal area of the nipple of a six-year-old bitch. Furthermore, an extensive literature review of hibernomas in animals was made. Physical examination revealed a nodular lesion in the subepidermal area of the third nipple of the left mammary chain. The histopathological findings included lobules of round to oval cells with abundant pale to eosinophilic cytoplasm, containing one or multiple optically empty vacuoles, consistent with nipple hibernoma. Immunohistochemically, the neoplastic cells were negative for cytokeratin AE1/AE3 and p53 but showed strong immunoreaction for vimentin and uncoupling protein-1, thus confirming the brown adipose tissue origin. Local recurrence was not detected after 18 months of follow-up. Hibernomas are rare and benign neoplastic lesions, originating from brown adipose tissue. Due to their histological and molecular resemblance with liposarcoma, a correct diagnosis of these neoplasms is required. In addition, the literature review suggests that hibernomas may present different features, according to species.

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Section: Discussionmentioning

confidence: 99%

Nipple Hibernoma in a Dog: A Case Report With Literature Review

et al. 2021

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“…This tumor was defined by Merkel just about a hundred years ago firstly who called as "pseudolipoma". In 1914, Gery gived the name of hibernoma to this tumor because of its similarity to hibernating animals brown fat (1,6). Hibernomas regard as about 2% of all benign lipomatous neoplasia (2).…”

Section: Discussionmentioning

confidence: 99%

“…Hibernomas are a unusual, benign lipocytic neoplasias arising from persistent of brown fat resembling to the certain hibernating animal species (1). The brown adipocytic tissue has a position of thermogenesis in the early years of life, but it recedes with age.…”

Section: Introductionmentioning

confidence: 99%

A rare case of adipocytic tumor in subscapular region: hibernoma

Zengin

2019

Journal of Health Sciences and Medicine

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Hibernom kalıntı kahverengi adipoz dokudan ortaya çıkan, nadir görülen iyi huylu adipositik bir neoplazidir. Hibernom, klinik prezentasyonda liposarkomlar gibi malign tümörlere benzer, ancak bu tümör malignite potansiyeli ile ilişkilendirilmemiştir. Hibernomlar genellikle ağrısız, kapsüllü, sıklıkla yetişkinlerde görülen, sarı renkli yumuşak doku neoplazileridir. Santral çekirdek ve asidofilik-granüllü sitoplazması olan büyük hücrelerden oluşurlar. Bu yazıda, subskapular bölgeden kaynaklanan bir hibernomun histolojik ve klinik özellikleri tanımlanmıştır.

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