Cellular and humoral systemic and mucosal immune responses stimulated in volunteers by an oral polybacterial immunomodulator “Dentavax”

Петрунов, Богдан; Marinova, S.; Markova, Roumiana; Nenkov, P.; Nikolaeva, S P; Nikolova, Maria; Taskov, Hristo; Cvetanov, J.

doi:10.1016/j.intimp.2006.02.012

Cited by 19 publications

(11 citation statements)

References 50 publications

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“…It should be pointed out that Respivax treatment did not change the level of the proliferation inducing cytokine IL-2, in consensus with the results obtained for other similar preparations, Urostim and Dentavax [22,66]. Therefore, Respivax treatment does not induce a spontaneous proliferative response, which is an important requirement for any immunomodulating treatment.…”

Section: Discussionsupporting

confidence: 84%

Polybacterial immunomodulator Respivax restores the inductive function of innate immunity in patients with recurrent respiratory infections

Nikolova

Stankulova

Taskov

et al. 2009

International Immunopharmacology

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Section: Discussionsupporting

confidence: 84%

Polybacterial immunomodulator Respivax restores the inductive function of innate immunity in patients with recurrent respiratory infections

Nikolova

Stankulova

Taskov

et al. 2009

International Immunopharmacology

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“…Within the mucosal immune system, there is a significant degree of compartmentalization linking specific mucosal inductive sites with particular effector sites (e.g., the gut with mammary and salivary glands), which is partially due to the differential expression of chemokines, integrins and cytokines among mucosal tissues [3,4]. In line with this study, the oral intake of polybacterial immunomodulator Dentavax, containing killed Lactobacillus acidophilus , has been reported to induce a strain-specific IgA response in the saliva of healthy adults [27]. Likewise, the oral intake of fermented milk containing L. casei DN-114 001 has been shown to induce non-specific total SIgA in infant saliva [22].…”

Section: Discussionmentioning

confidence: 69%

Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial

et al. 2010

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BackgroundImmunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on salivary secretory IgA (SIgA) in the elderly has not been reported. The objective of this study was to demonstrate the acceleration of salivary SIgA secretion by oral intake of Lactobacillus pentosus strain b240 (b240) in the elderly.ResultsA total of 80 healthy elderly individuals were randomly allocated to either an intervention (i.e., b240) or a control (i.e., placebo) group. The elderly individuals in the b240 group were given a sterile water beverage (125 mL) containing heat-killed b240 (4 × 109 cells), while those in the placebo group were given only a sterile water beverage (125 mL); both groups received their respective beverages once daily for 12 weeks. Saliva was collected before initiation of the study and every 2 weeks thereafter. Saliva flow rate and SIgA concentration were determined, and the SIgA secretion rate was calculated. The mean salivary SIgA secretion rate in the b240 group steadily increased until week 4 (exhibiting a 20% elevation relative to that at week 0), and then remained stable until week 12. Changes in SIgA secretion rate over the intervention period were significantly greater in the b240 group than in the placebo group. The treatment groups exhibited no significant differences in adverse events.ConclusionsOral intake of L. pentosus strain b240 for 12 weeks significantly accelerated salivary SIgA secretion, thereby indicating its potential utility in the improvement of mucosal immunity and resistance against infection in the elderly.

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“…Furthermore, it has been surmised that at least in healthy individuals, the bacteria are scavenged from the bloodstream relatively quickly by the innate and adaptive defense mechanisms (20,100). Despite this general contention, some studies indicate that an episode of odontogenic bacteremia could last as long as 60 min (39,110,132), and most studies report the presence of bacterial species in blood for up to 30 min (Table 2; Fig.…”

Section: Temporal Nature Of Odontogenic Bacteremiamentioning

confidence: 99%

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

et al. 2009

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SUMMARY The human gingival niche is a unique microbial habitat. In this habitat, biofilm organisms exist in harmony, attached to either enamel or cemental surfaces of the tooth as well as to the crevicular epithelium, subjacent to a rich vascular plexus underneath. Due to this extraordinary anatomical juxtaposition, plaque biofilm bacteria have a ready portal of ingress into the systemic circulation in both health and disease. Yet the frequency, magnitude, and etiology of bacteremias due to oral origin and the consequent end organ infections are not clear and have not recently been evaluated. In this comprehensive review, we address the available literature on triggering events, incidence, and diversity of odontogenic bacteremias. The nature of the infective agents and end organ infections (other than endocarditis) is also described, with an emphasis on the challenge of establishing the link between odontogenic infections and related systemic, focal infections.

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Cellular and humoral systemic and mucosal immune responses stimulated in volunteers by an oral polybacterial immunomodulator “Dentavax”

Cited by 19 publications

References 50 publications

Polybacterial immunomodulator Respivax restores the inductive function of innate immunity in patients with recurrent respiratory infections

Polybacterial immunomodulator Respivax restores the inductive function of innate immunity in patients with recurrent respiratory infections

Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

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