Cellular and molecular basis of drug addiction: The role of neuronal ensembles in addiction

Liu, Xing; Wang, Feifei; Le, Qiumin; Ma, Lan

doi:10.1016/j.conb.2023.102813

Cited by 4 publications

(1 citation statement)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Addictive substances are strong Pharmaceuticals 2024, 17, 615 2 of 16 rewarding stimuli. Once the reward is delayed, the abuser will have a psychological desire to take the substance, resulting in the relapse behavior [13][14][15][16]. Therefore, interrupting the reward pathway and alleviating withdrawal symptoms are the keys to successful substance abuse rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Substance Addiction Rehabilitation Drugs

Yuan,

Jiang,

Zhang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs need to be developed urgently. There have been numerous reports on blocking the formation of substance addiction, but studies on drugs that can alleviate withdrawal symptoms are very limited. Both the dopamine transporter (DAT) hypothesis and D3 dopamine receptor (D3R) hypothesis are proposed. DAT activators reduce the extracellular dopamine level, and D3R antagonists reduce the neuron’s sensitivity to dopamine, both of which may exacerbate the withdrawal symptoms subsequently. The D3R partial agonist SK608 has biased signaling properties via the G-protein-dependent pathway but did not induce D3R desensitization and, thus, may be a promising drug for the withdrawal symptoms. Drugs for serotoninergic neurons or GABAergic neurons and anti-inflammatory drugs may have auxiliary effects to addiction treatments. Drugs that promote structural synaptic plasticity are also discussed.

show abstract

Section: Introductionmentioning

confidence: 99%