Cellular and Molecular Mechanism of Dermal Fibrosis Following Burn Injury, and Exploration of Therapeutic Approaches

Ding, Jie; Tredget, Edward E.

doi:10.4172/2472-1905.100003

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Transplanting Human Skin Grafts onto Nude Mice to Model Skin Scars

Ding

Tredget

2017

Fibrosis

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Hypertrophic scar (HTS) is a common outcome of deep dermal wound healing mainly followed mechanical, chemical, and thermal injuries in the skin. Because of the lack of the most effective prevention and treatment, it is particularly important to establish an ideal dermal animal model for improving the understanding of the pathogenesis and exploring therapeutic approaches of HTS. Compared to other dermal fibrotic animal models in rabbits, red Duroc pigs, guinea pigs, rats, and mice, the approach that uses normal human split-thickness skin grafted onto nude or other immunodeficient mice which develop scars that resemble human HTS offers the advantages of lower cost, easier manipulation, and shorter research period. In this chapter, we will introduce the detailed procedures to create the ideal dermal fibrotic mouse model.

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