Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells

Ito, Tomoki; Liu, Yongjun; Arima, Kazuhiko

doi:10.2332/allergolint.11-rai-0376

Cited by 83 publications

(85 citation statements)

References 82 publications

(111 reference statements)

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“…TSLP is an epithelial cell-derived cytokine that regulates T-cell differentiation by conditioning DC maturation (15). It was also reported that TSLP expression in patients with AD was associated with LC migration and activation (15,16). In this study, we tested whether TRPV3 acted as a DC modulator by controlling the TSLP response in DS-Nh mice.…”

Section: Trpv3 and Tslp Are Up-regulated In The Skin Of Patients With Admentioning

confidence: 93%

Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

Yamamoto-Kasai

Yasui

Shichijo

et al. 2013

Experimental Dermatology

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The transient receptor potential channel vanilloid subfamily V member 3 (TRPV3), which functions as a thermosensor in keratinocytes, plays an important role in the development of allergic and itchy dermatitis in rodents. Although real-time PCR analysis using lesional and non-lesional skin samples from patients with atopic dermatitis showed that TRPV3 was expressed in lesional skin, the role that TRPV3 plays in patients with dermatitis is still relatively obscure. Here, we determined whether TRPV3 was a dendritic cell (DC) modulator using DS-Nh mice with a gain-of-function mutation in TRPV3 (TRPV3Gly573Ser), because increasing skin temperature is associated with the modulation of dermal dendritic cells (DCs). Interestingly, increased responses to haptens by skin and DCs were observed in DS-Nh mice compared with those from DS mice with wild-type TRPV3. Increased thymic stromal lymphopoietin (TSLP) responses were also observed in keratinocytes from DS-Nh mice compared with those from DS mice. Taken together, we propose that the DS-Nh mouse is a good model to use in order to better understand the role of this orphan channel and that TRPV3 may represent a new therapeutic target in certain types of dermatitis through the control of DCs.

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Section: Trpv3 and Tslp Are Up-regulated In The Skin Of Patients With Admentioning

confidence: 93%

Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

Yamamoto-Kasai

Yasui

Shichijo

et al. 2013

Experimental Dermatology

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“…The clinical condition of type I hypersensitivity is attributable to a functional imbalance of type 1 and type 2 helper CD4 + T cells (Th1 and Th2 cells, respectively) caused by epithelial cell-derived cytokines including thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33. Under this condition, Th2 cells secrete IL-4, IL-5 and IL-13 to promote unfavorable immune responses by helping B cells to produce allergen-specific IgE in the airway [4][5][6]. However, the mechanism by which AR deteriorates to AR + Asthma, which is a more serious form of allergic airway diseases, is still unclear.…”

Section: Introductionmentioning

confidence: 93%

Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma

Kamekura

Shigehara

Miyajima

et al. 2015

Clinical Immunology

100

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Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR+Asthma). To determine the pathophysiologic features of AR and AR+Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR+Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR+Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR+Asthma cases. Moreover, we found significant correlations of fractional exhaled nitric oxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma.

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“…Thymic stromal lymphopoietin (TSLP), a cytokine produced in response to both environmental and endogenous factors, contributes to disorders and homeostasis [1][2][3][4]. Highly expressed in keratinocytes in the lesions of atopic dermatitis patients and bronchial epithelial cells in asthma patients, TSLP plays a key role in allergic diseases through its effect on dendritic cells [5][6][7] and other types of cells [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

Xie

Takai

Xue

et al. 2012

Journal of Dermatological Science

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Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells

Cited by 83 publications

References 82 publications

Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

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