Cellular and molecular mechanisms of renal carcinogenesis induced by avian erythroblastosis virus

Induction of renal adenocarcinoma by a nonmutated erbB oncogene

“…The proliferating epithelial cells appeared to be in the distal convoluted tubule or collecting ducts, as the proximal tubules and glomeruli were normal. The histologic characteristics of the tumors were comparable to those reported for the AEV-ES4and td359-induced renal cell tumors (3,18). Mutations at the serine 477/478 phosphorylation site of erbB that enhance the ability to induce wing web tumors (32) did not significantly affect the histologic characteristics of the renal adenocarcinoma (Fig.…”

“…AEV-ES4 has been reported to cause renal adenocarcinoma as well as erythroblastosis and fibrosarcoma (3; for a review, see reference 15). td359, a variant of AEV-ES4 that is defective for erbA and contains a C-terminal truncation of erbB, causes renal adenocarcinoma and fibrosarcoma in the absence of erythroblastosis (6,18). Here we show that a nonmutated erbB can cause renal adenocarcinoma as well as erythroblastosis.…”

“…Very little has been reported about the disease status of kidneys from erbB-infected birds in previous experiments. Two erbB viruses, AEV-ES4 and td359, have been shown to induce renal adenocarcinoma (3,18). Both of these erbB viruses contain mutations (4, 6) that have been demonstrated to cause broadening of erbB disease potential (30).…”

Metastatic cholangiocellular carcinoma and renal adenocarcinoma in a golden eagle(Aquila chrysaetos)

“…Similarly, high prevalences have been associated with avian erythroblastosis virus (Nogueira et al, 1992) and leukosis virus (Payne & Purchase, 1991). In the present case, no structure suggestive of a virus was identified by electron microscopy.…”