Cellular and Molecular Mechanisms Underlying Pain Chronicity

Simonetti, Manuela; Mauceri, Daniela

doi:10.3390/cells12081126

Cells

2023

DOI: 10.3390/cells12081126

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Cellular and Molecular Mechanisms Underlying Pain Chronicity

Manuela Simonetti

Daniela Mauceri

Abstract: Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]

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2024

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Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives

García-Domínguez

2024

Front. Aging

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Chronic pain is a debilitating condition frequently observed in the elderly, involving numerous pathological mechanisms within the nervous system. Diminished local blood flow, nerve degeneration, variations in fiber composition, alterations in ion channels and receptors, accompanied by the sustained activation of immune cells and release of pro-inflammatory cytokines, lead to overactivation of the peripheral nervous system. In the central nervous system, chronic pain is strongly associated with the activation of glial cells, which results in central sensitization and increased pain perception. Moreover, age-related alterations in neural plasticity and disruptions in pain inhibitory pathways can exacerbate chronic pain in older adults. Finally, the environmental influences on the development of chronic pain in the elderly must be considered. An understanding of these mechanisms is essential for developing novel treatments for chronic pain, which can significantly improve the quality of life for this vulnerable population.

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Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives

García-Domínguez

2024

Front. Aging

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Cellular and Molecular Mechanisms Underlying Pain Chronicity

Abstract: Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]

Cited by 1 publication

References 25 publications

Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives

Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives

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