Cellular and molecular mechanisms underlying plasticity in uterine sympathetic nerves

Brauer, M. Mónica

doi:10.1016/j.autneu.2008.02.002

Cited by 28 publications

(16 citation statements)

References 114 publications

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“…29,30 It is therefore not unexpected that genes such as TEK (also known as Tie-2) and KDR (also known as VEGF-R2) are significantly down in F compared to myometrium, since these 2 tyrosine kinase receptors are expressed primarily in endothelial cells. Defects in TEK are associated with inherited venous malformations and the TEK-signalling pathway plays a critical role in endothelial cell-smooth muscle cell communication during venous morphogenesis.…”

Section: Discussionmentioning

confidence: 99%

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

et al. 2013

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Despite the prevalence of uterine fibroids (Fs), few studies have investigated the links between clinical features and the cellular or molecular mechanisms that drive F growth and development. Such knowledge will ultimately help to differentiate symptomatic from asymptomatic Fs and could result in the development of more effective and individualized treatments. The aim of this study was to investigate the relationship between ultrasound appearance, blood flow, and angiogenic gene expression in F, perifibroid (PM), and distant myometrial (DM) tissues. We hypothesized that angiogenic gene expression would be increased in tissues and participants that showed increased blood flow by Doppler ultrasound. The study was performed using Doppler ultrasound to measure blood flow prior to hysterectomy, with subsequent tissue samples from the F, PM, and DM being investigated for angiogenic gene expression. Overall, PM blood flow (measured as peak systolic velocity [PSV]) was higher than F blood flow, although significant heterogeneity was seen in vascularity and blood flow between different Fs and their surrounding myometrium. We did not find any correlation between PSV and any other clinical or molecular parameter in this study. We identified 19 angiogenesis pathway-related genes with significant differences in expression between F and DM, and 2 genes, matrix metalloproteinase 9 (MMP9) and Neuropilin 2 (NRP2), that were significantly different between F and PM. These results are consistent with subtle differences between PM and DM. Understanding the differences between symptomatic versus asymptomatic Fs may eventually lead to more effective treatments that directly target the source of heavy menstrual bleeding.

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Section: Discussionmentioning

confidence: 99%

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

et al. 2013

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“…This is not surprising, because changes in the neuritogenic capacity of the adult uterus are thought to contribute to the estrogen-driven remodeling of sympathetic innervation during the natural estrous cycle and also to allow regeneration of sympathetic nerves following delivery (Brauer 2008). These observations highlight the contribution of substrate-bound signals, because organotypic patterning of neurites occurs without the intervention of any ongoing production of permissive or inhibitory signals by the living tissue.…”

Section: Substrate-bound Signals Contributes To Histotypic Patterningmentioning

confidence: 91%

“…Although the SCG does not normally innervate the uterus (Vera et al 1997;Houdeau et al 1998), their neurons have been shown to respond to several uterine-derived growth-promoting and growth-inhibiting signals in a way similar to that of uterineprojecting sympathetic neurons, both in vitro (KrizsanAgbas and Smith 2002;Krizsan-Agbas et al 2003, 2008 and in anterior eye chamber transplantation studies (Brauer et al 1998(Brauer et al , 2000.…”

Section: Animals and Treatmentsmentioning

confidence: 97%

“…Previous in vivo (Brauer et al 2000 and in vitro (Krizsan-Agbas and Smith 2002) studies have shown that, under the influence of estrogen, the uterine myometrium loses its ability to support its sympathetic innervation. Moreover, current evidence indicates that the estrogenized myometrium is a source of several locally produced, diffusible factors with negative effects on sympathetic nerve growth, including brain-derived neurotrophic factor (BDNF; Krizsan-Agbas et al 2003), pro-nerve growth factor (pro-NGF; Lobos et al 2005), neurotrimin (KrizsanAgbas et al 2008), and some secreted members of the class 3 semaphorins (Marzioni et al 2004;Richeri et al 2008;Brauer 2008). In addition to soluble factors, neurite outgrowth requires substrate-bound signals.…”

Section: Introductionmentioning

confidence: 97%

“…Although the contribution of progesterone to this plasticity still remains unclear, strong evidence suggests that estrogen is a key hormone regulating the remodeling of uterine sympathetic nerves in the non-pregnant female (for a review, see Brauer 2008). In sexually mature rats, the density of myometrial sympathetic nerves decreases during the estrogen-dominant phases of the sex cycle, and chronic exposure of adult ovariectomized rats to estrogen induces the pruning of mature intrauterine sympathetic nerves (Zoubina et al 1998.…”

Section: Introductionmentioning

confidence: 98%

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Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

et al. 2010

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In order to evaluate the contribution of substrate-bound factors to the extent and patterning of the sympathetic innervation of rat uterus following estrogen treatment, superior cervical ganglion explants from neonatal and adult ovariectomized rats were cultured on tissue sections of fresh frozen uterus from adult ovariectomized rats treated with estrogen or a vehicle. The main findings were: (1) neurite growth was greatly influenced by histological features of the underlying section; (2) on myometrial sections, neurites followed the orientation of the main axis of the longitudinally sectioned muscle cells; (3) neurites showed limited growth on transversally sectioned smooth muscle; (4) neuritic patterning was unaffected by a reduction in migrating ganglionic non-neuronal cells; (5) neurite outgrowth, but not non-neural cell migration, was markedly reduced on myometrial sections from rats treated with estrogen. These results suggest that adult myometrium continues to provide signals allowing the organotypic patterning and growth of sympathetic axons, that estrogen treatment modifies myometrial substrate properties so that it is less supportive for sympathetic neurite growth, and that adult sympathetic neurons retain their ability to recognize substrate-bound cues present in the myometrium. On endometrial sections, neurites formed radially symmetric halos, which were reduced in size on estrogen-treated endometrial substrates. Thus, changes in the neuritogenic capacity of the uterus underlie plasticity in uterine sympathetic nerves, and alterations in substrate-bound factors contribute to the diminished receptivity of the estrogenized uterus to its sympathetic innervation.

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Reproductive Tract Histology in South American Fur Seal Pups (Arctophoca australis)

Katz

Johansson

2017

The Anatomical Record

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In the present study, a detailed histological description of the female reproductive tract of South American fur seal (Arctophoca australis) pups has been conducted. The uterine tube was covered by cuboidal to columnar epithelium; nerve fibers were present in the mesosalpinx and beneath the muscular layer. The uterus was bipartitus; the endometrial surface of the horns was lined by a simple cuboidal or columnar epithelium with deep tubular glands; caudally ("the transition area"), the epithelium changed to pseudostratified columnar, few tubular glands were present and the myometrium increased in width. A bistratified epithelium internally coated the uterine body, whereas it changed to cylindrical stratified epithelium with a highly vascularized lamina propria and a strong muscular layer in the cervix; no endometrial glands were observed in this region. From the transition area of the uterus to the vagina there were several nerve fibers and ganglia belonging to the uterovaginalis plexus. In the vestibule, hymenal folds were poorly developed; adnexa structures included the major vestibular glands and a neurovascular structure similar to the vestibular bulb. Minor vestibular glands were associated with the clitoris. The skin of the perineum was lined by a keratinized stratified epithelium, pigmented, with sebaceous glands, sweat glands and hair follicles. This is the first detailed histological description of the reproductive tract of South American fur seal pups, including the glandular adnexa and nerve structures. These results contribute to the reproductive biology in Pinniped species, and give a better understanding of the utero-placental perfusion mechanism during diving. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:600-613, 2017. © 2016 Wiley Periodicals, Inc.

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Cellular and molecular mechanisms underlying plasticity in uterine sympathetic nerves

Cited by 28 publications

References 114 publications

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

Reproductive Tract Histology in South American Fur Seal Pups (Arctophoca australis)

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