2022
DOI: 10.3389/fnsyn.2022.902319
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Cellular basis of learning and memory in the carotid body

Abstract: The carotid body is the primary peripheral chemoreceptor in the body, and critical for respiration and cardiovascular adjustments during hypoxia. Yet considerable evidence now implicates the carotid body as a multimodal sensor, mediating the chemoreflexes of a wide range of physiological responses, including pH, temperature, and acidosis as well as hormonal, glucose and immune regulation. How does the carotid body detect and initiate appropriate physiological responses for these diverse stimuli? The answer to … Show more

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Cited by 6 publications
(1 citation statement)
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References 184 publications
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“…With respect to the control of breathing, it is known that microinjections of L-CSNO into the nTS increase minute ventilation in awake freely-moving rats by stereoselective-dependent mechanisms unrelated to the potential decomposition of L-CSNO to nitric oxide ( Lipton et al, 2001 ). At the peripheral level, the carotid body contains, numerous excitatory and inhibitory neurotransmitters released by primary glomus cells (PGCs) in response to changes in ventilation ( Prabhakar, 1994 ; Iturriaga and Alcayaga, 2004 ; Rey and Iturriaga, 2004 ; Bairam and Carroll, 2005 ; Kumar, 2007 ; Shirahata et al, 2007 ; Iturriaga et al, 2009 ; Nurse and Piskuric, 2013 ; Nurse, 2014 ; Gonkowski, 2020 ; Bardsley et al, 2021 ; Gold et al, 2022 ). However, there is no current agreement as to the identity of the primary neurotransmitter released by PGCs to drive the hypoxic ventilatory response ( Eyzaguirre and Fidone, 1980 ; Iturriaga and Alcayaga, 2004 ; Nurse, 2005 ; Lahiri et al, 2006 ; Iturriaga et al, 2009 ; Gonzalez et al, 2010 ; Prieto-Lloret and Aaronson, 2017 ; Aldossary et al, 2020 ; Gold et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…With respect to the control of breathing, it is known that microinjections of L-CSNO into the nTS increase minute ventilation in awake freely-moving rats by stereoselective-dependent mechanisms unrelated to the potential decomposition of L-CSNO to nitric oxide ( Lipton et al, 2001 ). At the peripheral level, the carotid body contains, numerous excitatory and inhibitory neurotransmitters released by primary glomus cells (PGCs) in response to changes in ventilation ( Prabhakar, 1994 ; Iturriaga and Alcayaga, 2004 ; Rey and Iturriaga, 2004 ; Bairam and Carroll, 2005 ; Kumar, 2007 ; Shirahata et al, 2007 ; Iturriaga et al, 2009 ; Nurse and Piskuric, 2013 ; Nurse, 2014 ; Gonkowski, 2020 ; Bardsley et al, 2021 ; Gold et al, 2022 ). However, there is no current agreement as to the identity of the primary neurotransmitter released by PGCs to drive the hypoxic ventilatory response ( Eyzaguirre and Fidone, 1980 ; Iturriaga and Alcayaga, 2004 ; Nurse, 2005 ; Lahiri et al, 2006 ; Iturriaga et al, 2009 ; Gonzalez et al, 2010 ; Prieto-Lloret and Aaronson, 2017 ; Aldossary et al, 2020 ; Gold et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%