Cellular behavior on TiO2 nanonodular structures in a micro-to-nanoscale hierarchy model

Kubo, Katsutoshi; Tsukimura, Naoki; Iwasa, Fuminori; Ueno, Takeshi; Saruwatari, Lei; Aita, Hideki; Chiou, Wen‐An; Ogawa, Takahiro

doi:10.1016/j.biomaterials.2009.06.021

Cited by 284 publications

(277 citation statements)

References 46 publications

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“…Several studies have demonstrated that implant surfaces a ect nanoscale topography and thereby alter cell behaviors or change the nanofeatures of structures to improve the osseointegration process [4,11,12]. e embed surface can be adjusted by various approaches to add nanoscale features to the surfaces in speci c combinations.…”

Section: Discussionmentioning

confidence: 99%

“…Materials with an expanded surface region and a better surface roughness may yield better mechanical interlocking between tissues and titanium [3]. However, more importantly, such nanoscale features are also believed to directly affect osteogenic cell behaviors around implant fixtures with nonconventional surfaces, creating a biomimetic relationship between alloplastic surfaces and host tissues by the replication of the natural cellular environment at the nanometer level [1,2,4]. Low-dimensional TiO 2 nanostructures have attracted recent attention because these materials can take the forms of nanotubes [5], nanofibers [6], and nanowires [7].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Tashiro

Komasa

Miyake

et al. 2018

Advances in Materials Science and Engineering

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We investigated the adsorption of albumin and fibronectin on a titania nanosheet-(TNS-) modified quartz crystal microbalance (QCM) sensor. A Ti QCM sensor was fabricated by reactive magnetron sputtering. A thin layer of Ti was deposited on the QCM sensor. is sensor was then alkali-modified by treatment with NaOH at room temperature to fabricate the titania nanosheets. Scanning probe microscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy were performed to investigate the surface topology and chemical components of each sensor. e TNS had a titanium oxide film exhibiting a nodular structure and a thickness of 13 nm on the QCM sensor. Furthermore, QCM measurements showed significantly greater amounts of albumin and fibronectin adsorbed on the TNS than on titanium. e NaOH treatment of titanium modified the sensor surface and improved the adsorption behaviors of proteins related to the initial adhesion of bone marrow cells. erefore, we concluded that TNS improves the initial adhesion between the implant materials and the surrounding tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Tashiro

Komasa

Miyake

et al. 2018

Advances in Materials Science and Engineering

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“…In addition, the importance of the nanostructure of the surfaces on biological response has been recently recognized 2) . Kubo et al showed that the addition of nanostructures to a micro-roughened implant surface stimulated the proliferation and differentiation of osteoblast cells with a synergistic effect 22) . Furthermore, Cochran et al showed that the ratio of bone contact on an SLA implant with a micro-and nanoporous surface was greater than that of a TPS implant with only a microporous surface 23) .…”

Section: Discussionmentioning

confidence: 99%

Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells

et al. 2015

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The purpose of this study was to investigate the influence of superhydrophilic treatments of titanium on the behavior of osteoblastlike cells. Superhydrophilic specimens were prepared with sandblast and acid-etching (DW), oxygen plasma (Plasma) and ultraviolet light (UV), and were stored in distilled water for 3 days immediately after these treatments. Specimens stored in air for 3 weeks were used as a control Air group. Initial cell attachment, proliferation, alkaline phosphatase activity, and osteocalcin secretion of mouse osteoblast-like cells MC3T3-E1 were enhanced more on superhydrophilic groups than were Air specimens. On confocal laser scanning microscope images of cell morphology, the expression of actin filaments was observed on the superhydrophilic groups, whereas relatively little actin filament expression was seen on the Air surfaces on all culture periods. These results indicate that DW, Plasma, or UV treatment has potential for the creation and maintenance of superhydrophilic surfaces and the enhancement of the initial attachment, proliferation, and differentiation of osteoblast-like cells.

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“…A combination of shot blasting and acid etching is often performed on Cp-Ti implants because it reportedly accelerates osseointegration [8][9][10][11][12][13][14][15] . In vitro experiments have demonstrated that the combination promotes adhesion, proliferation, and differentiation of osteoblasts [11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

“…In vitro experiments have demonstrated that the combination promotes adhesion, proliferation, and differentiation of osteoblasts [11][12][13][14][15] . In vivo experiments have demonstrated that it improves bone-implant contact and increases removal torque [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Influence of grade and surface topography of commercially pure titanium on fatigue properties

et al. 2018

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The objective was to investigate the influence of grade and surface topography of commercially pure titanium (Cp-Ti) on fatigue properties evaluated via staircase method. Cp-Ti grades 2 and 4 were roughened by shot blasting and acid etching, and compared with machined specimens. Yield force under static loading for Cp-Ti grades 2 and 4 were 672±51 and 1,088±93 N for machined and 724±99 and 1,118±96 N for roughened group. Yield force under cyclic loading for Cp-Ti grades 2 and 4 decreased 27 and 40% compared to static loading. Cp-Ti grade 4 demonstrated significantly greater decrease in yield force after cyclic loading; however surface topography had no effect.

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Cellular behavior on TiO2 nanonodular structures in a micro-to-nanoscale hierarchy model

Cited by 284 publications

References 46 publications

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Analysis of Titania Nanosheet Adsorption Behavior Using a Quartz Crystal Microbalance Sensor

Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells

Influence of grade and surface topography of commercially pure titanium on fatigue properties

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