Cellular biocompatibility and resistance to compression of macroporous β-tricalcium phosphate ceramics

Sous, M; Bareille, Reine; Rouais, F.; Clément, Denis; Amédée, Joëlle; Dupuy, B.; Baquey, C.

doi:10.1016/s0142-9612(98)00118-5

Cited by 94 publications

(57 citation statements)

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“…Chitosan addition was effective since it promoted foam stability and permitted scaffolds fabrication with lower contents of gelatin. Scaffolds with pore diameters ranging from 100 to 800 µm facilitate cell attachment and proliferation 16,17 . Moreover, making scaffolds of resorbable materials enhance its degradation rate permitting new bone tissue growth and improving implant osteointegration 6,[14][15][16]18 .…”

Section: Discussionmentioning

confidence: 99%

Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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Calcium phosphate cements (CPCs) have potential to be used on repairing damaged bones due to their moldability, bioactivity and bioresorbability. These materials combine calcium orthophosphate powders with a liquid leading to a paste that hardens spontaneously at low temperatures. Hence, CPCs could be applied as scaffolds to support cell/tissue growth. This paper studies CPC scaffolds processing by foaming cement's liquid phase in which was added gelatin and chitosan. The former acted to increase the foam stability while the ladder acted as a foaming agent. Moreover, these polymers would enhance scaffold's biological properties by controlling material's total porosity and in vivo resorption. The method proposed led to scaffolds with 58.71% porosity with sizes ranging from 160 to 760 µm and compressive strength of 0.70MPa. After foaming, pores' size, distribution and interconnectivity changed significantly leading to a material that could be applied on bone regeneration since it would allow nutrient's transport, cell attachment and an increase in material degradation rate.

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Section: Discussionmentioning

confidence: 99%

Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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“…Control of the microporosity and roughness of the ceramic walls and struts will also help to manipulate cell attachment and osseointegration, issues that will be addressed in the future work. Compressive strength of lamellar HA scaffolds prepared by freeze casting vs. reported values for materials fabricated using conventional techniques [2][3][4][5][6][7][8][9][10]. The typical pore sizes of conventional porous HA scaffolds are on the order of 100 to 800 µm in order to allow bone ingrowth.…”

Section: Discussionmentioning

confidence: 99%

“…Our preliminary tests indicate that the compressive strength of the robocasted grids ranges between 25 to 40 MPa. This is of the order of porous calcium phosphates with similar porosity (~ 45 %) fabricated by conventional techniques [2][3][4][5][6][7][8][9][10] and slightly higher than the corresponding value for cancellous bone (7-10 MPa) [20]. No de-bonding of the lines was observed during testing, indicating excellent adhesion between the printed lines.…”

Section: Robocastingmentioning

confidence: 98%

“…The scaffold must provide the necessary support for cells to proliferate and slowly degrade and resorb as the tissue structures grow in vitro and/or in vivo [1]. In conventional porous scaffold fabrication methods [2][3][4][5][6][7][8][9][10] it is difficult to precisely control pore size, geometry and spatial distribution, to create internal channels within the scaffold for vascularization, and to produce scaffolds with arbitrary and complex 3-D anatomical shapes.…”

Section: Introductionmentioning

confidence: 99%

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Porous ceramic scaffolds with complex architectures

Munch

Franco

Deville

et al. 2008

JOM

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This work compares two novel techniques for the fabrication of ceramic scaffolds for bone tissue engineering with complex porosity: robocasting and freeze casting. Both techniques are based on the preparation of concentrated ceramic suspensions with suitable properties for the process. In robocasting, the computer-guided deposition of the suspensions is used to build porous materials with designed three dimensional (3-D) geometries and microstructures. Freeze casting uses ice crystals as a template to form porous lamellar ceramic materials. Preliminary results on the compressive strengths of the materials are also reported.

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“…In bulk, β-TCP bioceramics have mechanical properties too poor to be used in load-bearing clinical applications [17][18][19], which has been attributed to the difficulties in fully densifying β-TCP powders [18,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Densification and Mechanical Behavior of β-Tricalcium Phosphate Bioceramics

Mehdikhani

Borhani

2014

ILCPA

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Nano-size β-tricalcium phosphate powders with average grain size of 80 nm were prepared by the wet chemical precipitation method with calcium nitrate and di-ammonium hydrogen phosphate as calcium and phosphorus precursors, respectively. The precipitation process employed was also found to be suitable for the production of sub-micrometre β-TCP powder in situ. The sinterability of the nano-size powders, and the microstructure, mechanical strength of the prepared β-TCP bioceramics were investigated. Bioceramic sample characterization was achieved by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), and density measurements. Powders compacted and sintered at 800, 900, 1000 and 1100 °C showed an increase in relative density from 70 % to 93 %. The results revealed that the maximum hardness of 240 H V was obtained for β-TCP sintered at 1100 °C.

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Cellular biocompatibility and resistance to compression of macroporous β-tricalcium phosphate ceramics

Cited by 94 publications

References 0 publications

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Porous ceramic scaffolds with complex architectures

Densification and Mechanical Behavior of β-Tricalcium Phosphate Bioceramics

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