Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult

Hollister, William R.; Baust, John M.; Buskirk, Robert G. Van; Baust, John G.

doi:10.1089/15383440260682099

Cited by 11 publications

(9 citation statements)

References 50 publications

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“…These differences can be identified in single, short freezing cycles. Experiments show that the temperatures at which the differences in cell sensitivity can be identified are in the range of 0 to −30°C [59,88]. Sebaceous glands and hair follicles were also lost in this warm freezing range, but keratinocyctes survived at −30°C.…”

Section: The Cryogenic Lesionmentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: The Cryogenic Lesionmentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…The remodeling is facilitated by pressure within the vessel, and intima hyperplasia tends to regress over the following months (Gage 2004). Hollister et al (2003) examined the response of monolayers of human smooth muscle cells and endothelial cells to freezing. The results of their work showed that smooth muscle cells were more sensitive to cold injury than endothelial cells, with clear evidence in the temperature range of 0 to -15°C.…”

Section: Cryoplastymentioning

confidence: 99%

Biothermal Modeling of Post-Cryoplasty Atheroscelerosis in Restenotic Patients

Men-Chi

Ravigururajan

2007

Cardiovasc Eng

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Atherosclerosis is a leading cause of heart diseases and mortality around the world. Recently, cryoplasty has emerged as a potential alternative method to treat arterial atherosclerosis. Finite element heat transfer and mass transfer models are developed using ANSYS in this study. The model analyzes the heat transfer within the atherosclerotic plaque and arterial wall during the cryoplasty procedure. The model is useful in predicting the transient temperature through the diseased wall tissues. The results may be used to decide required treatment procedure to effectively freeze the plaque with minimal damage to the healthy arterial tissues. Finally, the model investigates the parameters that may effect temperature distribution within the tissues during the ablative procedure.

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“…A pertinent investigation by Hollister et al 88 accurately defines the cryotherapeutic goal, which is to apply the cooling temperature that will preserve the endothelial cells and ablate the smooth muscle cells. Their work subjected cultured endothelial and smooth muscle cells of the coronary artery to a range of hypothermic and freezing temperatures.…”

Section: Selective Cryotherapymentioning

confidence: 99%

Selective Cryotherapy

Gage¹

2004

Cell Preservation Technology

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Freezing tissue in situ produces a response that ranges from inflammatory to destructive. The nature of the response is related to the severity of the cryogenic injury, which is dependent upon the tissue temperature, the duration of freezing, and other factors in the freeze-thaw cycle. Therefore, by adjusting the freeze-thaw cycle to an appropriate program, the tissue response may be manipulated to achieve a selected goal. Selective cryotherapy depends on differences in the sensitivity of cells to cold injury. Most normal cells die at rather elevated freezing temperatures, but the fibrocollagenous matrix is preserved, which yields a favorable healing of the wound. Cancer cells are resistant to freezing injury and require low freezing temperatures and repeated freeze-thaw cycles. These differences permit exploration of the expanded uses of cryoablative techniques. This review focuses on the two faces of cryotherapy, that is, its destructive and preservative aspects. The efficacy of cryosurgery for tumors may be increased by adjunctive therapy, which will influence the fate of cells in an apoptotic state in the frozen volume. Tissue warming techniques can prevent destruction in unwanted areas. The current and potential use of warmer freezing temperatures features selective destruction of some cells, while avoiding injury to others, and selective functional compromise of cells with later return of function. Elevated freezing temperatures may also be used to elicit a non-destructive response to induce changes in the process of healing. These tissue responses and adjunctive therapy provide the direction for future research and therapy.

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Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult

Cited by 11 publications

References 50 publications

Experimental cryosurgery investigations in vivo

Experimental cryosurgery investigations in vivo

Biothermal Modeling of Post-Cryoplasty Atheroscelerosis in Restenotic Patients

Selective Cryotherapy

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