Cellular Degradation Machineries in Age-Related Loss of Muscle Mass (Sarcopenia)

Altun, Mikael; Grönholdt‐Klein, Max; Wang, Lingzhan; Ulfhake, Brun

doi:10.5772/34274

Cited by 13 publications

(15 citation statements)

References 79 publications

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“…These factors reduce the quality of life of the elderly patients and eventually cause their loss of autonomy in daily life. Sarcopenia is the age-related loss of the muscle mass and strength, which causes frailty, functional limitations in daily living, disabilities, and, finally, a higher mortality rate in the elderly patients (2).…”

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confidence: 99%

Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

Niu

Guo

et al. 2013

The Journals of Gerontology Series A: Biological Sciences and M

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Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells. Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls. These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.

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mentioning

confidence: 99%

Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

Niu

Guo

et al. 2013

The Journals of Gerontology Series A: Biological Sciences and M

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“…The plasticity in myofibre twitch characteristics and thus myosin type expression is partly preserved in adulthood as elegantly shown in cross‐innervation experiment more than half a century ago . The fact that hybrid fibres occur in low frequency of naïve controls suggests that a low‐level of denervation/re‐innervation takes place also in young intact animals ( idem ), a remodelling phenomenon that increases with advancing age where the re‐innervation may fail and underpin muscle wasting during ageing (sarcopenia) …”

Section: Discussionmentioning

confidence: 96%

“…69 The fact that hybrid fibres occur in low frequency of naïve controls suggests that a low-level of denervation/ re-innervation takes place also in young intact animals (idem), a remodelling phenomenon that increases with advancing age where the re-innervation may fail and underpin muscle wasting during ageing (sarcopenia). 13,15,17,18 Concomitant with the shift in frequency of MyHC I and II, there is a transient re-expression of the embryonic isoform of MyHC signalling denervation. 11,27 The increase in eMyHC immunoreactive protein was accompanied by a re-expression of the CHNR-γ subunit.…”

Section: Discussionmentioning

confidence: 99%

“…To measure pace and extent of functional recovery after the crush injury, the animals were subjected to a standardized set of behavioural tests on day 5,6,10,12,15,18,20,22,25,27 and 28 post-crush (dpc). All other animals used in the study were tested only 4 dpc and the day before sacrifice for longer survival points (Figures 1,2).…”

Section: Behavioural Testmentioning

confidence: 99%

“…Denervation is a common course for disrupted function of skeletal muscles and it may origin in a trauma (ie, mechanical lesioning of the nerve trunk), infections, systemic diseases affecting, eg, the microvasculature of the peripheral nerves or diseases like amyotrophic lateral sclerosis . Denervation may also be a driving force in the loss of skeletal muscle strength and mass during normal ageing, ie, sarcopenia …”

Section: Introductionmentioning

confidence: 99%

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Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush

et al. 2019

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Aim To resolve timing and coordination of denervation atrophy and the re‐innervation recovery process to discern correlations indicative of common programs governing these processes. Methods Female Sprague‐Dawley (SD) rats had a unilateral sciatic nerve crush. Based on longitudinal behavioural observations, the triceps surae muscle was analysed at different time points post‐lesion. Results Crush results in a loss of muscle function and mass (−30%) followed by a recovery to almost pre‐lesion status at 30 days post‐crush (dpc). There was no loss of fibres nor any significant change in the number of nuclei per fibre but a shift in fibres expressing myosins I and II that reverted back to control levels at 30 dpc. A residual was the persistence of hybrid fibres. Early on a CHNR ‐ε to ‐γ switch and a re‐expression of embryonic MyHC showed as signs of denervation. Foxo1, Smad3, Fbxo32 and Trim63 transcripts were upregulated but not Myostatin, InhibinA and ActivinR2B. Combined this suggests that the mechanism instigating atrophy provides a selectivity of pathway(s) activated. The myogenic differentiation factors (MDFs: Myog, Myod1 and Myf6) were upregulated early on suggesting a role also in the initial atrophy. The regulation of these transcripts returned towards baseline at 30 dpc. The examined genes showed a strong baseline covariance in transcript levels which dissolved in the response to crush driven mainly by the MDFs. At 30 dpc the naïve expression pattern was re‐established. Conclusion Peripheral nerve crush offers an excellent model to assess and interfere with muscle adaptions to denervation and re‐innervation.

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Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study

Meng

Hong-lei

Pei

et al. 2017

Sci Rep

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Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. One hundred and ninety-four subjects enrolled into this multicenter, randomized, double-blind, placebo-controlled study. Subjects received either placebo(Group 1), pRJ 1.2 g/d(Group 2), or 4.8 g/d(Group 3). Data through 1 year are reported for 163 subjects. The primary outcome measure is handgrip strength. Secondary outcomes include several physical performance tests (six-minute walk test, timed up and go test, and standing on one leg with eyes closed). The dropout rate was 16.0%. The means (95% confidence interval) of change in handgrip strength for placebo, low-dose, and high-dose groups are −0.98(−2.04,0.08), 0.50(−0.65,1.65) and 1.03(−0.37,2.44) kg (P = 0.06, P for trend = 0.02), respectively. No significant effects of the interventions were observed for physical performances. These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. In addition, we have not found that pRJ intervention can achieve improvement or attenuating the decrease in physical performance.

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Cellular Degradation Machineries in Age-Related Loss of Muscle Mass (Sarcopenia)

Cited by 13 publications

References 79 publications

Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush

Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study

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