Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina

Hirano, Arlene A.; Brandstätter, Johann Helmut; Brecha, Nicholas C.

doi:10.1002/cne.20577

Cited by 57 publications

(93 citation statements)

References 107 publications

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“…However, there is no evidence for centersurround receptive fields in mouse rod bipolar cells (Bloomfield and Xin, 2000). Although it has not yet been shown directly, the presence of HC feedback in mammalian rods is suggested by the anatomical finding that axon terminals of B-type HCs make synaptic contacts exclusively with rods (Hirano et al, 2005;Pan and Massey, 2007). (2) A second possible function of HC-to-rod feedback is suggested by the finding that HC feedback contributes to light adaptation in cones (Burkhardt, 1995).…”

Section: Discussionmentioning

confidence: 99%

Feedback from Horizontal Cells to Rod Photoreceptors in Vertebrate Retina

Thoreson¹,

Babai²,

Bartoletti³

2008

J. Neurosci.

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Retinal horizontal cells (HCs) provide negative feedback to cones, but, largely because annular illumination fails to evoke a depolarizing response in rods, it is widely believed that there is no feedback from HCs to rods. However, feedback from HCs to cones involves small changes in the calcium current (I Ca ) that do not always generate detectable depolarizing responses. We therefore recorded I Ca directly from rods to test whether they were modulated by feedback from HCs. To circumvent problems presented by overlapping receptive fields of HCs and rods, we manipulated the membrane potential of voltage-clamped HCs while simultaneously recording from rods in a salamander retinal slice preparation. Like HC feedback in cones, hyperpolarizing HCs from Ϫ14 to Ϫ54, Ϫ84, and Ϫ104 mV increased the amplitude of I Ca recorded from synaptically connected rods and caused hyperpolarizing shifts in I Ca voltage dependence. These effects were blocked by supplementing the bicarbonate-buffered saline solution with HEPES. In rods lacking light-responsive outer segments, hyperpolarizing neighboring HCs with light caused a negative activation shift and increased the amplitude of I Ca . These changes in I Ca were blocked by HEPES and by inhibiting HC light responses with a glutamate antagonist, indicating that they were caused by HC feedback. These results show that rods, like cones, receive negative feedback from HCs that regulates the amplitude and voltage dependence of I Ca . HC-to-rod feedback counters light-evoked decreases in synaptic output and thus shapes the transmission of rod responses to downstream visual neurons.

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Section: Discussionmentioning

confidence: 99%

Feedback from Horizontal Cells to Rod Photoreceptors in Vertebrate Retina

Thoreson¹,

Babai²,

Bartoletti³

2008

J. Neurosci.

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“…The protein syntaxin-1 was recognized as a specific marker of retinal amacrine and horizontal cells by several research teams (Barnstable et al, 1985;Nag and Wadhwa, 2001;Hirano et al, 2005;Li et al, 2010). Mouse anti-syntaxin (HPC-1; Sigma) recognized syntaxin-1, a 35-kDa protein, from hippocampal, retinal, and cortical neurons (Inoue et al, 1992).…”

Section: Cb1 Receptors In the Developing Retinamentioning

confidence: 99%

Cannabinoid receptor type 1 expression during postnatal development of the rat retina

Zabouri

Bouchard

Casanova

2011

J of Comparative Neurology

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Cannabinoid receptor type 1 (CB1R) participates in developmental processes in the central nervous system (CNS). The rodent retina represents an interesting and valuable model for studying CNS development, because it contains well-identified cell types with clearly established and distinct developmental timelines. Very little is known about the distribution or function of CB1R in the developing retina. In this study, we investigated the expression pattern of CB1R in the rat retina during all stages of postnatal development. Western blots were performed on retinal tissue at different time points between P1 and adulthood. In order to identify the cells expressing the receptor and the age at which this expression started, immunohistochemical co-staining was carried out for CB1R and markers of the different cell types comprising the retina. CB1R was already present at P1 in various cell types, i.e., ganglion, amacrine, horizontal, and mitotic cells. In the course of development, it appeared in cone photoreceptors and bipolar cells. For some cell types (bipolar, Müller, and some amacrine cells), CB1R was transiently expressed, suggesting a potential role of this receptor in developmental processes, such as migration, morphological changes, sub-identity acquisition, and patterned retinal spontaneous activity. Our results also indicated that CB1R is largely expressed in the adult retina (cone photoreceptors and horizontal, most amacrine, and retinal ganglion cells), and may therefore contribute to retinal functions. Overall these results indicate that, as shown in other structures of the brain, CB1R could play an instrumental role in the development and function of the retina.

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“…All tissue was labeled using the indirect fluorescence technique as described previously [23,44]. Retinal sections were briefly dipped in 0.1 M PB before being warmed for 10 minutes at 37°C.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina

Stella¹,

Li²,

Sabatini³

et al. 2008

Brain Research

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Glutamate is the major excitatory neurotransmitter in the retina, and most glutamatergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3). However, the expression profiles of these transporters vary greatly in the retina. VGLUT1 is expressed by photoreceptor and bipolar cell terminals, and VGLUT2 appears to be predominately expressed by ganglion cells, and perhaps Müller cells, cone photoreceptor terminals, and horizontal cells in some species. The discovery of a third vesicular glutamate transporter, VGLUT3, has brought about speculation concerning its role and function based on its expression in amacrine cells. To address this we studied the postnatal development of VGLUT3 from day 0 through adult in the rat retina, and compared this with the expression patterns of VGLUT1 and VGLUT2. VGLUT3 expression was restricted to a population of amacrine cells. Expression of VGLUT3 was first observed at postnatal day 10 (P10) in the soma and some processes, which extensively arborized in both the ON and OFF sublamina of the IPL by P15. In contrast, VGLUT1 and VGLUT2 expression appeared earlier than VGLUT3; with VGLUT1 initially detected at P5 in photoreceptor terminals and P6 in bipolar terminals, and VGLUT2 immunoreactivity initially detected at P0 in ganglion cell bodies, and remained prominent throughout all stages of development. Interestingly, VGLUT3 has extensive somatic expression throughout development, which could be involved in non-synaptic modulation by glutamate in developing retina, and could influence trophic and extra-synaptic neuronal signaling by glutamate in the inner retina.

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Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina

Cited by 57 publications

References 107 publications

Feedback from Horizontal Cells to Rod Photoreceptors in Vertebrate Retina

Feedback from Horizontal Cells to Rod Photoreceptors in Vertebrate Retina

Cannabinoid receptor type 1 expression during postnatal development of the rat retina

Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina

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