Cellular diversity of the somatosensory cortical map plasticity

Kole, Koen; Scheenen, Wim J.J.M.; Tiesinga, Paul; Celikel, Tansu

doi:10.1101/201293

Cited by 8 publications

(8 citation statements)

References 221 publications

(282 reference statements)

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“…Experience-dependent cortical plasticity studies revealed multiple critical periods. More recent studies are expanding the concept of critical periods and barrel cortex plasticity to cellular and molecular levels involving neurons, glia, and endothelial cells (and adaptive changes at the molecular levels) (Kole et al, 2018).…”

Section: Critical-period Plasticitymentioning

confidence: 99%

How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective

Erzurumlu

Gaspar

2020

J. Neurosci.

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For half a century now, the barrel cortex of common laboratory rodents has been an exceptionally useful model for studying the formation of topographically organized maps, neural patterning, and plasticity, both in development and in maturity. We present a historical perspective on how barrels were discovered, and how thereafter, they became a workhorse for developmental neuroscientists and for studies on brain plasticity and activity-dependent modeling of brain circuits. What is particularly remarkable about this sensory system is a cellular patterning that is induced by signals derived from the sensory receptors surrounding the snout whiskers and transmitted centrally to the brainstem (barrelettes), the thalamus (barreloids), and the neocortex (barrels). Injury to the sensory receptors shortly after birth leads to predictable pattern alterations at all levels of the system. Mouse genetics have increased our understanding of how barrels are constructed and revealed the interplay of the molecular programs that direct axon growth and cell specification, with activity-dependent mechanisms. There is an ever-rising interest in this sensory system as a neurobiological model to study development of somatotopy, patterning, and plasticity at both the morphologic and physiological levels. This article is part of a group of articles commemorating the 50th anniversary of the Society for Neuroscience.

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Section: Critical-period Plasticitymentioning

confidence: 99%

How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective

Erzurumlu

Gaspar

2020

J. Neurosci.

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“…Combined with the systematic molecular, structural and functional reconstruction (see e.g. (Meyer et al, 2010(Meyer et al, , 2013Narayanan et al, 2015;Huang et al, 2016;Kole et al, 2017bKole et al, , 2017aKole et al, , 2018da Silva Lantyer et al, 2018;Kole and Celikel, 2019)) of the these circuits, a comprehensive multi-scale computational map of sensorimotor computation is evolving.…”

Section: Discussionmentioning

confidence: 99%

Development of adaptive motor control for tactile navigation

Azarfar¹,

Celikel²

2019

Preprint

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Navigation is a result of complex sensorimotor computation which requires integration of sensory information in allocentric and egocentric coordinates as the brain computes a motor plan to drive navigation. In this active sensing process, motor commands are adaptively regulated based on prior sensory information. In the darkness, rodents commonly rely on their tactile senses, in particular to their whiskers, to gather the necessary sensory information and instruct navigation. Previous research has shown that rodents can process whisker input to guide mobility even prior to whisking onset by the end of the second postnatal week, however, when and how adaptive sensorimotor control of whisker position matures is still not known. Here, we addressed this question in rats longitudinally as animals searched for a stationary target in darkness. The results showed that juvenile rats perform object localization by controlling their body, but not whisker position, based on the expected location of the target. Adaptive, closed-loop, control of whisker position matures only after the third postnatal week. Computational modeling of the active whisking showed the emergence of the closed-loop control of whisker position and reactive retraction, i.e. whisker retraction that ensures the constancy of duration of tactile sampling, facilitate the maturation of sensorimotor exploration strategies during active sensing. These results argue that adaptive motor control of body and whiskers develop sequentially, and sensorimotor control of whisker position emerges later in postnatal development upon the maturation of intracortical sensorimotor circuits. database to study the principles of active sensing in freely navigating rodents. Gigascience 7, 2018b. Behrens TEJ, Muller TH, Whittington JCR, Mark S, Baram AB, Stachenfeld KL, Kurth-Nelson Z. What is a cognitive map? organizing knowledge for flexible behavior. Neuron 100: 490-509, 2018. Bender KJ, Rangel J, Feldman DE. Development of columnar topography in the excitatory layer 4 to layer 2/3 projection in rat barrel cortex. J Neurosci 23: 8759-8770, 2003. Berg RW, Kleinfeld D. Rhythmic whisking by rat: retraction as well as protraction of the vibrissae is under active muscular control. J Neurophysiol 89: 104-117, 2003. Carvell GE, Simons DJ. Biometric analyses of vibrissal tactile discrimination in the rat. J Neurosci 10: 2638-2648, 1990. Carvell GE, Simons DJ. Task-and subject-related differences in sensorimotor behavior during active touch. Somatosens Mot Res 12: 1-9, 1995. Celikel T, Marx V, Freudenberg F, Zivkovic A, Resnik E, Hasan MT, Licznerski P, Osten P, Rozov A, Seeburg PH, Schwarz MK. Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory. Front Neurosci 1: 97-110, 2007. Celikel T, Sakmann B. Sensory integration across space and in time for decision making in the somatosensory system of rodents. A. The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell 5: 178-190, 2009. Cramer NP, K...

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“…For electrochemical measurements of neurotransmitters, quartz capillaries were heated for 60 s, dipped in CNTs dispersed in Nafion solution (5 mg mL -1 in ethanol). Electrochemical measurements were carried in artificial cerebrospinal fluid (aCSF) as described before (Kole, 2015;Kole et al, 2017bKole et al, , 2017aKole et al, , 2018 and included 135mM NaCl, 5.4mM KCl, 5mM Na-HEPES buffer, 1.8mM CaCl 2 and 1mM of MgCl 2 .…”

Section: Electrochemical Setupmentioning

confidence: 99%

Simultaneous Detection of Dopamine and Serotonin with Carbon-based Electrodes

Khot

Shirtcliffe

Celikel

2021

Preprint

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Graphite-based materials, like pyrolyzed carbon electrodes, are widely used as implantable electrochemical sensors, for the detection of neurotransmitters, neuromodulators, and gaseous species, thanks to their strong mechanical properties, superior electron-transfer kinetics, and in-vivo stability. Electrochemical properties of graphite can be improved by coating them with carbon nanotubes (CNTs) which improves sensitivity, selectivity, and resistance to biofouling. Although several types of electrodes have been developed to detect biologically relevant targets like monoamines, multiplexed sensing of dopamine and serotonin is not yet widely available. Herein we introduce pyrolyzed carbon electrodes coated with CNTs for fast scan cyclic voltammetry for simultaneous detection of dopamine and serotonin with a sensitivity of 52/microM and 5nA/microM, respectively. Serotonin shows a broad oxidation peak at 0.68V. When dopamine and serotonin are probed simultaneously at 10 Hz, dopamine oxidizes at 0.1V 0.1 and serotonin oxidizes at 0.78V and dopamine reduces at -0.35V and serotonin at 0.1V. Thus the sensors shows discrimination between dopamine and serotonin and are suitable for simultaneous detection of these monoamines. Keywords: Carbon nanotubes, Electrochemistry, Dopamine, Serotonin, Anti-fouling Surfaces

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Cellular diversity of the somatosensory cortical map plasticity

Cited by 8 publications

References 221 publications

How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective

How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective

Development of adaptive motor control for tactile navigation

Simultaneous Detection of Dopamine and Serotonin with Carbon-based Electrodes

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