Cellular factors involved in CXCL8 expression induced by glycated serum albumin in vascular smooth muscle cells

Choi, Kyung-Ha; Park, Jae-Woo; Kim, Hye-Young; Kim, Young‐Hee; Kim, Sunmi; Son, Yonghae; Park, Young-Chul; Eo, Seong-Kug; Kim, Koanhoi

doi:10.1016/j.atherosclerosis.2009.08.030

Cited by 22 publications

(15 citation statements)

References 35 publications

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“…The decrease in the amount of CXCR1 and CXCR2 present on the cell membrane was not only due to degradation but also curcumin may affect the ligand-promoted trafficking pathway of the CXCR1 and CXCR2. Curcumin delayed the trafficking pathway in the cytosol, and this resulted in the blockage of the recycling pathway to the cell surface [71][72][73].…”

Section: Curcumin Inhibit Proinflammatory Cytokines Chemokines and Omentioning

confidence: 99%

Curcumin has bright prospects for the treatment of multiple sclerosis

Xie

Takahara

2011

International Immunopharmacology

100

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Section: Curcumin Inhibit Proinflammatory Cytokines Chemokines and Omentioning

confidence: 99%

Curcumin has bright prospects for the treatment of multiple sclerosis

Xie

Takahara

2011

International Immunopharmacology

100

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“…Sixth, curcumin prevented accumulation of AGEs [113] by trapping methylglyoxal [114] in human umbilical vein endothelial cells. Seventh, curcumin suppressed glycated-serum-albumin-(GSA-)induced IL-8 upregulation [115] via promoter activation and enhanced CXCL8 release in vascular smooth muscle cells. Eighth, curcumin attenuated diabetes-induced vascular dysfunction through inhibition of cyclooxygenase-2 (COX-2) activity, NF- κ B, and PKC and by improving the ratio of prostanoid products PGI(2)/TXA(2) in STZ rats [116].…”

Section: Curcumin and Diabetic Vascular Diseasementioning

confidence: 99%

Curcumin and Diabetes: A Systematic Review

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

259

175

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Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family, has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine. The active component of turmeric, curcumin, has caught attention as a potential treatment for diabetes and its complications primarily because it is a relatively safe and inexpensive drug that reduces glycemia and hyperlipidemia in rodent models of diabetes. Here, we review the recent literature on the applications of curcumin for glycemia and diabetes-related liver disorders, adipocyte dysfunction, neuropathy, nephropathy, vascular diseases, pancreatic disorders, and other complications, and we also discuss its antioxidant and anti-inflammatory properties. The applications of additional curcuminoid compounds for diabetes prevention and treatment are also included in this paper. Finally, we mention the approaches that are currently being sought to generate a “super curcumin” through improvement of the bioavailability to bring this promising natural product to the forefront of diabetes therapeutics.

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“…On the other hand, although in vivo E. coli-induced vascular dysfunction was TLR4 dependent, the functional change showed only an incomplete necessity of both MyD88 and TRIF signaling (10). In addition, studies by Choi et al (11) employing a glycated serum albumin induced inflammatory response in vascular muscle demonstrated a requirement for TLR4 and signaling through both MyD88 and TRIF adaptor proteins. Therefore, the literature would suggest that intestinal smooth muscle cells could potentially participate as nonprofessional immunocytes in the early MyD88-dependent development of ileus and the generation of various inflammatory mediators but that, additionally, smooth muscle cell TRIF signaling might also contribute.…”

Section: Discussionmentioning

confidence: 95%

Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus

Buchholz

Billiar

Bauer

2010

American Journal of Physiology-Gastrointestinal and Liver Physi

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TLR4 ligation by pathogen-associated molecular patterns, such as Gram-negative bacteria-derived LPS, triggers a nonhematopoietic cell-mediated ileus during early endotoxemia. Our objective was to investigate the quantitative contributions of the two downstream signaling pathways of TLR4, namely the adapter proteins myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF). Six hours after intraperitoneal injection of highly purified LPS (UP-LPS, 5 mg/kg), in vivo gastrointestinal transit and intestinal muscularis gene transcripts of inflammatory mediators chemokine (C-X-C motif) ligand 10, synonymous IP-10 (CXCL10), granulomonocyte colony stimulating factor (GM-CSF, synonymous CSF-2), IL-1beta, IL-6, IL-10, and inducible NO synthase (iNOS) were assessed in mice with transgenic loss-of-function for MyD88 or TRIF. LPS-induced MyD88 and TRIF mRNA upregulation was quantified within the intestinal muscularis of TLR4-competent and TLR4-mutant mice, and MyD88 mRNA levels were additionally measured in TLR4 bone marrow chimeras. MyD88 deficiency completely protected mice from early endotoxin-induced ileus, while TRIF deficiency partially ameliorated ileus severity. LPS induction of the primary downstream signaling element MyD88 was TLR4 dependent and was derived in equal amounts from both the hematopoietic and the nonhematopoietic cells. Conversely, no induction of TRIF mRNA was detectable. Significant gene induction of all inflammatory mediators was dependent on intracellular signal transduction by MyD88, while the TRIF MyD88-independent pathway predominantly regulated the molecular levels of CXCL10. In summary, MyD88 and TRIF are nonredundant signaling pathways in early endotoxin-induced rodent ileus, but MyD88 is the essential adaptor molecule for transduction of early TLR4-induced ileus and inflammatory signaling. The dependency of ileus on individual adaptor protein pathways is also reflected in the manifestation of specific molecular inflammatory events within the intestinal muscularis externa.

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Cellular factors involved in CXCL8 expression induced by glycated serum albumin in vascular smooth muscle cells

Cited by 22 publications

References 35 publications

Curcumin has bright prospects for the treatment of multiple sclerosis

Curcumin has bright prospects for the treatment of multiple sclerosis

Curcumin and Diabetes: A Systematic Review

Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus

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