Cellular fatty acid-binding proteins: Their function and physiological significance

Glatz, Jan F. C.; Vusse, Ger J.

doi:10.1016/s0163-7827(96)00006-9

Cited by 521 publications

(409 citation statements)

References 386 publications

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“…Although their complete tertiary structure, gene organization, and binding properties are known, the functional aspects of these proteins are still undergoing investigation. FABP's protective role is evidenced by: (1) controlling the availability of free fatty acids and their metabolites in the cytosol, and which prevents their cellular toxicity 14,15 ; (2) modulating the interaction of fatty acids with nuclear receptors 16 ; (3) sequestrating or removing cytotoxic drugs 17 ; and (4) trapping or scavenging ROS. 4,[18][19][20][21] However, no significant protective effects of FABP had been observed for chemical-induced anoxia or transport of intracellular fatty acid using the FABP-transfected kidney cell (MDCK) model.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative Function of L-FABP in L-FABP Stably Transfected Chang Liver Cells *

et al. 2005

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C ellular oxidative stress is one of the factors responsible for the propagation of liver diseases, such as hepatitis, cirrhosis, and hepatoma. 1 Several primary antioxidant defense systems such as superoxide dismutase (SOD), catalase, glutathione (GSH), and glutathione peroxidase are present intracellularly. These systems scavenge reactive oxygen species (ROS) such as hydrogen peroxide, superoxide, lipid peroxides, and free radicals. Exposure to oxidative stress may, however, deplete the cellular antioxidant capacity. Therefore, other antioxidant defense systems are expected to play an important role in oxidative stress.Liver fatty acid binding protein (L-FABP) is a 14-kd protein found abundantly in the cytoplasm and the nucleus of hepatocytes. 2,3 L-FABP is very likely to be an effective endogenous antioxidant, because it has high affinity and capacity to bind long-chain fatty acid oxidation products. 4,5 Hepatocyte L-FABP concentration could be as high as 0.4 mmol/L, 6 and it contains a large number of reducing amino acid residues (1 cysteine and 7 methionine residues) in its molecular structure. With an accessible volume enclosed by the molecular surface of L-FABP of 28,600 Å 3,7 the concentration of total methionine residues in L-FABP could be as high as approximately 400 mmol/L. Methionine and cysteine amino acids are regarded as cellular scavengers of activated xenobiotics and

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Section: Discussionmentioning

confidence: 99%

Antioxidative Function of L-FABP in L-FABP Stably Transfected Chang Liver Cells *

et al. 2005

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“…31 In a study to evaluate the clinical usefulness of B-FABP as a biomarker of brain injury, Pelsers et al 32 reported that B-FABP could be detected in the serum of 68% of the mild TBI patients examined. No B-FABP could be detected in the serum of healthy volunteer controls.…”

Section: Fatty Acid Binding Proteinsmentioning

confidence: 99%

Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury

et al. 2010

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“…Fatty acids can rapidly cross lipid bilayers such as those in the syncytiotrophoblast by simple diffusion and partition (Kamp et al, 1995), although a number of fatty acidbinding proteins (FABPs) have been identified in the membrane and cytoplasm of mammalian cells, which can reversibly and noncovalently bind fatty acids (Glatz & vanderVusse, 1996). These proteins are upregulated in conditions of increased cellular fatty acid metabolism and are thought to facilitate the transfer across membranes and intracellular channelling of fatty acids (Veerkamp et al, 1991(Veerkamp et al, , 2000Glatz & vanderVusse, 1996;Glatz et al, 1997b). The main membrane-associated FABPs are the plasma membrane fatty acid binding protein (FABPpm) and the fatty acid transfer proteins (FAT/CD36 and FATP).…”

Section: Maternalmentioning

confidence: 99%

“…The main membrane-associated FABPs are the plasma membrane fatty acid binding protein (FABPpm) and the fatty acid transfer proteins (FAT/CD36 and FATP). The FAT/CD36 and FATP are thought to span the lipid bilayer and function as fatty acid transporters/translocases, while the peripheral membrane protein FABPpm is thought to act as an extracellular fatty acid acceptor (Glatz & vanderVusse, 1996;Glatz et al, 1997a, b). Dutta-Roy and colleagues have demonstrated the presence of FAT/CD36 and FATP on both the microvillous and basal membranes of the placenta and the presence of a placenta-specific protein (p-FABPpm) exclusively on the microvillous membrane.…”

Section: Maternalmentioning

confidence: 99%

Effect of placental function on fatty acid requirements during pregnancy

Haggarty¹

2004

Eur J Clin Nutr

187

156

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The fetus has an absolute requirement for the n-3/n-6 fatty acids and docosahexaenoic acid (22:6 n-3; DHA) in particular is essential for the development of the brain and retina. Most of the fat deposition in the fetus occurs in the last 10 weeks of pregnancy. The likely rate of DHA utilisation during late pregnancy cannot be met from dietary sources alone in a significant proportion of mothers. De novo synthesis makes up some of the shortfall but the available evidence suggests that the maternal adipose tissue makes a significant contribution to placental transport to the fetus. The placenta plays a crucial role in mobilising the maternal adipose tissue and actively concentrating and channelling the important n-3/n-6 fatty acids to the fetus via multiple mechanisms including selective uptake by the syncytiotrophoblast, intracellular metabolic channelling, and selective export to the fetal circulation. These mechanisms protect the fetus against low long-chain polyunsaturated fatty acid (LCPUFA) intakes in the last trimester of pregnancy and have the effect of reducing the maternal dietary requirement for preformed DHA at this time. As a result of these adaptations, small changes in the composition of the habitual maternal diet before pregnancy are likely to be more effective in improving LCPUFA delivery to the fetus than large dietary changes in late pregnancy. There is little evidence that DHA intake/status in the second half of pregnancy affects visual and cognitive function in the offspring, but more studies are needed, particularly in children born to vegetarian and vegan and mothers who may have very low intakes of DHA.

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Cellular fatty acid-binding proteins: Their function and physiological significance

Cited by 521 publications

References 386 publications

Antioxidative Function of L-FABP in L-FABP Stably Transfected Chang Liver Cells *

Antioxidative Function of L-FABP in L-FABP Stably Transfected Chang Liver Cells *

Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury

Effect of placental function on fatty acid requirements during pregnancy

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