Cellular imaging of visual cortex reveals the spatial and functional organization of spontaneous activity

Ch'ng, Yeang H.; Reid, R. Clay

doi:10.3389/fnint.2010.00020

Cited by 32 publications

(31 citation statements)

References 38 publications

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“…Our results, using a technique with cellular resolution in awake mice, extend the study by Kenet et al (19) and demonstrate that the ensembles that are active spontaneously are also activated by visual stimuli. Our results are also consistent with the finding that a pair of neurons with the same preference for oriented gratings exhibits higher cell-to-cell correlation during spontaneous activity than a pair of neurons with a preference for orthogonally oriented gratings in anesthetized animals (37).…”

Section: Discussionsupporting

confidence: 92%

Visual stimuli recruit intrinsically generated cortical ensembles

Miller

Ayzenshtat

Carrillo-Reid

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

299

365

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The cortical microcircuit is built with recurrent excitatory connections, and it has long been suggested that the purpose of this design is to enable intrinsically driven reverberating activity. To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calcium imaging of populations of neurons from the primary visual cortex of awake mice during visual stimulation and spontaneous activity. In both conditions, cortical activity is dominated by coactive groups of neurons, forming ensembles whose activation cannot be explained by the independent firing properties of their contributing neurons, considered in isolation. Moreover, individual neurons flexibly join multiple ensembles, vastly expanding the encoding potential of the circuit. Intriguingly, the same coactive ensembles can repeat spontaneously and in response to visual stimuli, indicating that stimulus-evoked responses arise from activating these intrinsic building blocks. Although the spatial properties of stimulus-driven and spontaneous ensembles are similar, spontaneous ensembles are active at random intervals, whereas visually evoked ensembles are time-locked to stimuli. We conclude that neuronal ensembles, built by the coactivation of flexible groups of neurons, are emergent functional units of cortical activity and propose that visual stimuli recruit intrinsically generated ensembles to represent visual attributes.

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Section: Discussionsupporting

confidence: 92%

Visual stimuli recruit intrinsically generated cortical ensembles

Miller

Ayzenshtat

Carrillo-Reid

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

299

365

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“…The cortical spread of LFP was found to vary significantly across cortical layers in macaque V1, from 150 lm in layer 4B to 280 lm in layer 2/3 (Xing et al, 2009). For comparison, correlations in spontaneous neuronal spiking activity in cat visual cortex have been shown to fall to 50% within 240 lm (Ch'ng and Reid, 2010).…”

Section: Factors Influencing Spatiotemporal Dynamicsmentioning

confidence: 97%

Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography

Kellis

Sorensen

Darvas

et al. 2016

Clinical Neurophysiology

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“…Moreover, SOMs disinhibit layer 4 through powerful inhibition of PVs [44]. Thus we expect that during lasting high frequency neocortical activity, such as is seen spontaneously and in response to sensory stimuli in vivo [45,46], there is a rapid-onset, transient blanket of inhibition by PVs which is later replaced by a slowly recruited, persistent blanket mediated by SOMs.…”

Section: Early and Late Blanket Inhibitionmentioning

confidence: 99%

A blanket of inhibition: functional inferences from dense inhibitory connectivity

Karnani¹,

Agetsuma²,

Yuste³

2014

Current Opinion in Neurobiology

163

127

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The function of neocortical interneurons is still unclear, and, as often happens in biology, one may be able to draw functional insights from considering the structure. In this spirit we describe recent structural results and discuss some potential functional implications. In particular, many GABAergic interneurons appear to innervate nearby pyramidal neurons very densely and without any apparent specificity within their immediate vicinity, as if they were extending a “blanket of inhibition”, contacting them often in an overlapping fashion. While it is clear that subtypes of interneurons specifically target subcellular compartments of pyramidal cells, and they also target different layers selectively, they appear to treat all neighboring pyramidal cells the same and innervate them en masse. We explore the functional implications and temporal properties of dense, overlapping inhibition by four interneuron populations.

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Cellular imaging of visual cortex reveals the spatial and functional organization of spontaneous activity

Cited by 32 publications

References 38 publications

Visual stimuli recruit intrinsically generated cortical ensembles

Visual stimuli recruit intrinsically generated cortical ensembles

Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography

A blanket of inhibition: functional inferences from dense inhibitory connectivity

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