Cellular imaging properties of phosphorescent iridium(<scp>iii</scp>) complexes substituted with ester or amide groups

Dai, Peiling; Li, Jiangshan; Tang, Man; Yan, Dong; Xu, Zihan; Li, Yonghua; Chen, Zejing; Liu, Shujuan; Zhao, Qiang; Zhang, Kenneth Yin

doi:10.1039/d2dt01551j

Cited by 6 publications

(2 citation statements)

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“…Zhao, Zhang, and co-workers have developed four iridium(III) complexes modified with an ester or amide group (53) as cellular imaging reagents. 138 These complexes have the same formal charge (+1) and similar lipophilicity (log P o/w = 1.45 to 2.14) and molecular size, with structural variations limited to one or two atoms. While complexes 53b− 53d specifically accumulate in the mitochondria with negligible nuclear uptake, the distribution of complex 53a between the cell nucleus and mitochondria is similar.…”

Section: Rhodium(iii)mentioning

confidence: 99%

“…These findings highlight the significance of lipophilicity in governing the cellular uptake and intracellular localization properties of these complexes. Zhao, Zhang, and co-workers have developed four iridium(III) complexes modified with an ester or amide group ( 53 ) as cellular imaging reagents . These complexes have the same formal charge (+1) and similar lipophilicity (log P o/w = 1.45 to 2.14) and molecular size, with structural variations limited to one or two atoms.…”

Section: Luminescent Transition Metal Complexes For Bioimagingmentioning

confidence: 99%

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Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

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Section: Rhodium(iii)mentioning

confidence: 99%

Section: Luminescent Transition Metal Complexes For Bioimagingmentioning

confidence: 99%