Cellular Imbalance of the Hippocampus in Drug-Resistant Epilepsy (On the Question of the Role of the Hippocampus in Epileptogenesis)

Sitovskaya, D. А.; Semenov, Konstantin K.; Moschenko, Sofia S.; Sokolova, Tatyana V.; Zabrodskaya, Yu. M.

doi:10.56618/20712693_2022_14_3_80

Cited by 1 publication

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“…Some authors believe that the growth (springing) of mossy fibers is a compensatory-restorative process [58]. Comparison of the two groups (with and without epilepsy) against the totality of the neuron density values and glia cellularity allows us to state that the hippocampus in patients with DRE is a homogeneous cluster, regardless of the degree of morphological changes, which indicates the formation of a specific "epileptic" hippocampus in this category of patients [59].…”

Section: Hippocampal Sclerosismentioning

confidence: 96%

Epileptic Focus in Drug-Resistant Epilepsy: Structure, Organization, and Pathophysiology

Zabrodskaya¹,

Gaykova²,

Alexandrov³

et al. 2023

Epilepsy - Seizures Without Triggers

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The chapter focuses on how different cutting-edge techniques can be used to study electrophysiological, pathomorphological, and biochemical changes in the “epileptic focus” area of the cerebral cortex and white matter to see how epileptic seizures become drug-resistant and how it affects the other regions of the brain. The authors highlight the significance of neuroinflammation and apoptosis in the epilepsy pathogenesis providing EEG characteristics and describing structural changes in the cortex and white matter under such conditions as focal cortical dysplasia and epileptic leukoencephalopathy. Particular focus is given to structural and functional changes in the hippocampus and the role of hippocampal sclerosis in epilepsy. Key conceptions regarding the epileptic focus formation are outlined.

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Section: Hippocampal Sclerosismentioning

confidence: 96%