Cellular immunity in human malignant melanoma and melanoma histology

Cameron-Mowat, D. E.; Aj, Cochran; Grant, R M; Thomas, Catherine E.; Rm, MacKie; Spilg, W. G. S.

doi:10.1038/bjc.1973.79

Br J Cancer

1973

DOI: 10.1038/bjc.1973.79

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Cellular immunity in human malignant melanoma and melanoma histology

D. E. Cameron-Mowat¹,

Cochran Aj²,

R M Grant³

et al.

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Cited by 31 publications

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Breast cancer and the immune response

Tee

Pettingale

1974

Journal of British Surgery

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Patients with malignant disease including that of the breast may show specific immune reactions against their own tumours, and as the disease progresses other immune reactions may be depressed. The current controversy surrounding regional lymph node therapy in early breast cancer is discussed. Ideas about the further imniunological investigation of patients with breast cancer are outlined. ReferencesALEXANDER P. and HALL J. G . (1970) The role of immunoblasts in host resistance and immunotherapy of primary sarcomata. Adv. Cancer Res. 13, 1-37. AL-SARRAF M., WONG P., SARDESIA s. and VAITREVICUS v. K. (1970) Clinical immunological responsiveness in malignant disease. (i) Delayed hypersensitivity reaction and the effects of cytotoxic drugs.

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Breast cancer and the immune response

Tee

Pettingale

1974

Journal of British Surgery

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Immunosuppression in Burkitt's lymphoma. I. Cutaneous reactivity to recall antigens: Alterations induced by a tumour burden and by BCG administration

Magrath¹

1974

Intl Journal of Cancer

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Patients with Burkitt's lymphoma have impaired delayed hypersensitivity to recall antigens (mumps, streptokinase‐streptodornase candidin and PPD) in the presence of a tumour load. The degree of impairment at presentation (which may reach total anergia) is dependent upon the clinical stage and correlates significantly with survival rate (p < 0.02), sustained remission rate (p < 0.05) and remission duration (p < 0.01). Cutaneous reactivity 3 months after chemotherapy is significantly improved overall in spite of the potentially immunosuppressant effects of cyclophosphamide but immuno‐suppression recurs in patients who relapse. BCG, applied by dermal scarification resulted, after 4 weeks, in significant improvement of cutaneous reactivity (p < 0.001), but no improvement in prognosis. The most probable explanation of these findings is that the impairment in delayed hypersensitivity correlates with the tumour volume, which in turn governs prognosis. The level of general immunological responsiveness at presentation seems unlikely to be a crucial factor per se in governing the response to chemotherapy.

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Sensitization to tumour‐associated antigens in human breast carcinoma

Grant

Spilg

et al. 1974

Intl Journal of Cancer

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Cellular immunity in human malignant melanoma and melanoma histology

Cited by 31 publications

References 0 publications

Breast cancer and the immune response

Breast cancer and the immune response

Immunosuppression in Burkitt's lymphoma. I. Cutaneous reactivity to recall antigens: Alterations induced by a tumour burden and by BCG administration

Sensitization to tumour‐associated antigens in human breast carcinoma

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