Cellular Immunity Standard Values in Macaca Fascicularis

Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other - 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.

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Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys

Agrba

Karal-ogly

Gvozdik

et al. 2018

Bull Exp Biol Med

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Cellular Immunity Standard Values in Macaca Fascicularis

Abstract: Cellular immunity of clinically healthy Macaca fascicularis was studied by fl ow cytometry with monoclonal antibodies. Parameters of cellular immunity in Macaca fascicularis and Macaca rhesus virtually coincided and were maximally close to those in humans.

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Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys

Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys

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