Cellular immunohistopathology of acute, subacute, and chronic synovitis in rheumatoid arthritis.

Konttinen, Yrjö T.; Bergroth, Ville; Nordström, Dan; Koota, K; Skrifvars, Bo; Hagman, Gosta; Friman, Claes; Hämäläinen, Martti; Slätis, P

doi:10.1136/ard.44.8.549

Cited by 48 publications

(29 citation statements)

References 17 publications

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“…Such differences in human RA and heterologous CIA may also be reflected in the cellular composition of synovial cell membrane preparations. Immunohistologic studies of RA membranes have shown the presence of infiltrating T cells, plasma cells, monocyte-macrophage-like cells, granulocytes, and NK cells (39,40). In agreement, studies in this laboratory show that human RA membrane preparations contain ∼60% CD45+ cells, with the remainder being fibroblast-like cells (not shown).…”

Section: Discussionsupporting

confidence: 74%

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Page

Turner

Brown

et al. 2010

The Journal of Immunology

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Section: Discussionsupporting

confidence: 74%

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Page

Turner

Brown

et al. 2010

The Journal of Immunology

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“…2). It was reported that although monocytes and neutrophils predominate in acute onset RA, the most typical feature of prolonged synovitis in chronic RA is characterized by the presence of large T cell and plasma cell infiltrates (32). Further investigation may be necessary regarding the exact role of ENO1-positive neutrophils.…”

Section: Discussionmentioning

confidence: 99%

α-Enolase Expressed on the Surfaces of Monocytes and Macrophages Induces Robust Synovial Inflammation in Rheumatoid Arthritis

Bae

Kim

Lee

et al. 2012

The Journal of Immunology

111

124

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α-Enolase (ENO1) is a multifunctional glycolytic enzyme expressed abundantly in the cytosol. It has been implicated in autoimmune and inflammatory diseases. Serum Abs against ENO1 were reported in rheumatoid arthritis (RA). Cell-surface expression of ENO1 has been found to be increased rapidly in response to inflammatory stimuli, but its expression and function has not been reported in RA. In this study, we show that cell-surface expression of ENO1 is increased on monocytes and macrophages isolated from RA patients but not on those from osteoarthritis patients, and Ab against ENO1 can stimulate these cells to produce higher amounts of proinflammatory mediators, such as TNF-α, IL-1 α/β, IFN-γ, and PGE2 via p38 MAPK and NF-κB pathway. The frequency of ENO1-positive cells in synovial fluid mononuclear cells was higher than PBMCs. ENO1-positive cells were also found in the inflamed synovium from RA patients and arthritic ankle tissues of mice with collagen-induced arthritis. Taken together, these findings suggest that Abs against ENO1 present in RA sera may stimulate monocytes and macrophages expressing cell-surface ENO1 and contribute to production of proinflammatory mediators during the effector phase of synovial inflammation.

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“…As no grading schema has been proposed for haemophilic synovitis, a search of Medline was performed on 29 May 2006, using the term ÔSynovial Membrane/ *pathologyÕ and identified 1284 citations, of which the titles and abstracts were surveyed by one of the authors [17,18,[31][32][33][34][35][36][37][38][39] and used to guide the development of this schema.…”

Section: Grading Schemamentioning

confidence: 99%

Histological changes in murine haemophilic synovitis: a quantitative grading system to assess blood‐induced synovitis

Valentino

Hakobyan

2006

Haemophilia

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Haemophilia is a congenital disorder that results in frequent bleeding into joints, in which a chronic and debilitating arthritis develops. The presence of blood evokes an inflammatory and proliferative synovial reaction. Although the molecular mechanisms and biochemical pathways which underlie this disorder are not known, significant advances have been made by studying a murine model of human haemophilic synovitis. In order to better understand and correlate the pathological, molecular and biochemical changes, it has become necessary to grade the histological changes observed. Despite a search of the literature and review of relevant publications, none of the currently utilized schemes were appropriate, and therefore a novel grading scheme was developed. After review of over 1000 histological sections, six characteristic changes were identified: (i) synovial hyperplasia; (ii) vascularity; (iii) discolouration by haemosiderin; (iv) the presence of blood (erythrocytes); (v) villus formation; and (vi) cartilage erosion. Synovial hyperplasia and vascularity were present in variable amounts and were quantitatively scored (0-3), while the other changes were qualitatively scored as absent or present (0 or 1). Application of the grading scheme was tested and a high interobserver correlation (greater than 80%) was found. The scheme was easy to learn even by novices, with no prior experience. The availability of the histological grading scheme for murine synovitis will allow for precise evaluation of the pathological changes following joint bleeding, and facilitate correlations with molecular and biochemical changes that lead to these changes.

show abstract

Cellular immunohistopathology of acute, subacute, and chronic synovitis in rheumatoid arthritis.

Cited by 48 publications

References 17 publications

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

α-Enolase Expressed on the Surfaces of Monocytes and Macrophages Induces Robust Synovial Inflammation in Rheumatoid Arthritis

Histological changes in murine haemophilic synovitis: a quantitative grading system to assess blood‐induced synovitis

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