Cellular-Level Visualization of Retinal Pathology in Multiple Sclerosis With Adaptive Optics

Hammer, Daniel X.; Kovalick, Katherine; Liu, Zhuolin; Chen, Chixiang; Saeedi, Osamah J.; Harrison, Daniel M.

doi:10.1167/iovs.64.14.21

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…At the University of Maryland, Hammer and colleagues used AO to study the retinas of one eye from 10 patients with MS, 4 of whom had a history of optic neuritis and compared the results with 9 similarly aged healthy controls. 1 As in prior studies, AO revealed the GCL layer to be 5–6 cells deep and found some hyperreflective cells in the INL, which were thought to be displaced RGCs in MS patients and controls. As expected, based on traditional OCT findings, MS patients had lower NFL and GCL thicknesses than controls.…”

Section: Hammer DX Kovalick K Liu Z Chen C Saeedi Oj Harrison Dm Cell...supporting

confidence: 57%

Literature Commentary

2024

Journal of Neuro-Ophthalmology

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In this issue of JNO Drs. Mark L. Moster, Marc Dinkin, and Deborah I. Friedman discuss the following six articles.Zhang L, Ouyang S, Chen L, Huang H, Ou Y, Tang X. Evaluation of subjective visual vertical and horizontal in patients with acoustic neuroma based on virtual reality. Front Neurosci. 2023;17:1264585.Westgate CSJ, Kamp-Jensen C, Israelsen IME, et al. Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration. Br J Pharmacol. 2024;181(1):70–86.Pogson JM, Shemesh A, Roberts DC, Zee DS, Otero-Milan J, Ward BK. Longer duration entry mitigates nystagmus and vertigo in 7-Tesla MRI. Front Neurol. 2023;14:1255105.Fang CEH, Bokre D, Wong SH. Clinical characteristics associated with secondary generalization in patients with ocular myasthenia gravis: a systematic review and meta-analysis. Neurology. 2023;101(16):e1594–e1605.Hammer DX, Kovalick K, Liu Z, Chen C, Saeedi OJ, Harrison DM. Cellular-level visualization of retinal pathology in multiple sclerosis with adaptive optics. Invest Ophthalmol Vis Sci. 2023;64(14):21.Chapelle AC, Rakic JM, Plant GT. The occurrence of intraretinal and subretinal fluid in anterior ischemic optic neuropathy: pathogenesis, prognosis, and treatment. Ophthalmology. 2023;130(11):1191–1200.

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Section: Hammer DX Kovalick K Liu Z Chen C Saeedi Oj Harrison Dm Cell...supporting

confidence: 57%

Literature Commentary

2024

Journal of Neuro-Ophthalmology

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“… 80 Deciphering the distinct types of glial activation during the early stages of the disease will be crucial for understanding disease mechanisms and devising targeted therapeutic approaches. This could be done via advanced high-resolution in vivo imaging, such as AO-OCT, as has been done in multiple sclerosis, 81 or a combination of histology and high-resolution in vivo imaging.…”

Section: Discussionmentioning

confidence: 99%

Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease

Ravichandran,

Snyder,

Alber

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose Neuroinflammation plays a significant role in the pathology of Alzheimer's disease (AD). Mouse models of AD and postmortem biopsy of patients with AD reveal retinal glial activation comparable to central nervous system immunoreactivity. We hypothesized that the surface area of putative retinal gliosis observed in vivo using en face optical coherence tomography (OCT) imaging will be larger in patients with preclinical AD versus controls. Methods The Spectralis II instrument was used to acquire macular centered 20 × 20 and 30 × 25-degrees spectral domain OCT images of 76 participants (132 eyes). A cohort of 22 patients with preclinical AD (40 eyes, mean age = 69 years, range = 60–80 years) and 20 control participants (32 eyes, mean age = 66 years, range = 58–82 years, P = 0.11) were included for the assessment of difference in surface area of putative retinal gliosis and retinal nerve fiber layer (RNFL) thickness. The surface area of putative retinal gliosis and RNFL thickness for the nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) map were compared between groups using generalized linear mixed models. Results The surface area of putative retinal gliosis was significantly greater in the preclinical AD group (0.97 ± 0.55 mm 2 ) compared to controls (0.68 ± 0.40 mm 2 ); F (1, 70) = 4.41, P = 0.039; Cohen's d = 0.61. There was no significant difference between groups for RNFL thickness in the 9 ETDRS sectors, P > 0.05. Conclusions Our analysis shows greater putative retinal gliosis in preclinical AD compared to controls. This demonstrates putative retinal gliosis as a potential biomarker for AD-related neuroinflammation.

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