Cellular localization of cytochrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway

Husøy, Astrid-Mette; Myers, Mark S.; Goksøyr, Anders

doi:10.1016/s0166-445x(96)00797-7

Cited by 58 publications

(21 citation statements)

References 42 publications

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“…(Hong et al, 2007), increased E2 in males could be a result of an increase in aro matase activity. In past, numerous studies indicated that exposure to OP pesticides induces or enhances the activity of P 450 enzy mes (Munkittrick et al, 1994;Bucheli & Fent, 1995, Husoy, Myers, & Goksoyr, 1996Dong et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Korkmaz¹,

DONMEZ²

2017

Turk. J. Fish. Aquat. Sci.

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Section: Discussionmentioning

confidence: 99%

Untitled

Korkmaz¹,

DONMEZ²

2017

Turk. J. Fish. Aquat. Sci.

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“…Many histological, histochemical, and enzyme cytochemical and biochemical parameters have been used to diagnose stress in the liver of marine teleosts, flatfish species in particular (e.g. Ko¨hler 1990;Carr et al 1991;Ko¨hler and Pluta 1995;Ko¨hler et al 1992Ko¨hler et al , 1998Husøy et al 1996;Vethaak and Wester 1996;Collier et al 1998;Myers et al 1998), notably, differences in the quantities of stored lipids and glycogen in the hepatocytes. Metabolism of these energy-rich storage products is variable, especially depending on water temperature, reproductive, and nutritional status, as well as age and state of health of the fish (Welsch and Storch 1973, and references therein).…”

Section: Introductionmentioning

confidence: 99%

Structure of and energy reserves in the liver of wild and cultured yellowtail flounder, Limanda ferruginea

Ree

Spurrell

2003

Marine Biology

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Knowledge of the structure and energy reserves, in the liver of commercially important fish species, is important in understanding metabolic processes and in assessing the impact of potential environmental physical and chemical stressors in both wild and cultured stocks. The present study investigated the microscopic morphology and histochemistry (total and neutral lipids, glycogen) of liver tissue of wild (3 + ) and cultured (1 + ) sexually immature female and male yellowtail flounder (Limanda ferruginea Storer), sampled in late April 2001. Hepatosomatic indices [HSI: (liver weight/body weight)liver weight)·100] of cultured fish were significantly higher than those of wild fish. Females in the cultured group had significantly lower HSIs than males. The liver of both wild and cultured L. ferruginea was interspersed with pancreatic tissue. The main components of the liver tissue were irregular cords of hepatocytes arranged in tubules which surrounded vascular sinusoids. The hepatocytes contained an abundance of lipid, much of which appeared to be neutral lipids, in both sexes of the cultured fish. Total and neutral lipid droplets were larger, and the area occupied by these droplets was significantly greater in both cultured females and males compared to the wild fish, suggesting lipidosis in the cultured fish. In the cultured fish these differences were sex-dependent, the females having significantly more total and neutral lipids in hepatocytes than the males. This suggests a potentially greater storage capacity in females and/or a higher lipid metabolism in males. There were no statistically significant differences in glycogen content between the cultured and wild fish, or between the sexes in both sampling groups.

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“…Many other biological responses to contaminant exposure (biomarkers) have been utilized as endpoints for in situ studies with fish. These include mortality (Mac et al 1990), liver histopathology (Husøy et al 1996;Mondon et al 2001), EROD induction (Haasch et al 1993;Beyer et al 1996;Mondon et al 2001), level of CYP1A1 mRNA (Haasch et al 1993), cellular localization of CYP1A induction (Husøy et al 1996), level of immunoreactive protein (Haasch et al 1993), cytochrome P450 monooxygenase (MFO) activity (DeFlora et al 1993; Barra et al 2001), plasma cortisol, glucose, and lactase levels (Teles et al 2004), PAH metabolites in bile (Barra et al 2001;Beyer et al 1996;DeFlora et al 1993;Kammann 2007), plasma as well as hepatic retinoid levels (Besselink et al 1998), micronucleus assay for genotoxicity (DeFlora et al 1993;Rocha et al 2009), and plasma aspartate aminotransferase (Beyer et al 1996).…”

Section: Estrogenicity (Vitellogenin Synthesis)mentioning

confidence: 99%

The versatile, changing, and advancing roles of fish in sediment toxicity assessment—a review

2010

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Purpose Sediments serve as integral and dynamic parts of our aquatic systems. Within the last 15 to 20 years, however, the scientific community has begun noticing deterioration of sediment quality at an alarming rate worldwide. Sediments are now harboring hazardous pollutants that can directly influence water quality, thereby creating very stressful conditions for aquatic life. As a consequence, global efforts were initiated in the early 1970s, to find ways to assess sediment quality. Because of their obvious ecological and economic significance, fish have remained a major taxonomic group for appraising the general quality of aquatic systems. However, for sediment risk assessment, fish have lagged behind invertebrates due to their mobility and generally, pelagic lifestyle. To our knowledge, this is the first paper that comprehensively presents and reviews the versatile role of fish in assessing the state of health of aquatic sediments.Main features Through a literature search of the more relevant and/or more recent studies, this review attempted to trace the development of the various approaches as well as to describe the future prospects of using fish as sentinels for sediment quality assessment. Initially, the use of whole fish (juveniles or adults) bioassays contributed immensely to our understanding of sediment contamination and ecotoxicology. But due to economic as well as ethical issues linked to the use of live vertebrates for toxicity testing, the approach has shifted to using fish cell cultures and fish embryos. Much newer approaches involving receptors and gene arrays in fish cells to elucidate the mode of action of sediment-borne contaminants are very promising. The review paper also lists and explores some of the issues associated with the use of juvenile or adult fish, fish cell cultures, fish embryos, and fish gene expression profiles in sediment toxicity evaluations to stimulate further discussions, and hopefully, to serve as benchmark for future handling of similar or related aspects of fish utilization in sediment risk assessment. Conclusions and perspectives Overall, the present review has comprehensively explored the changing and progressing roles of fish in sediment toxicity evaluation. Indeed the usefulness of this taxon as test organisms has provided a significant contribution to the advancement of sediment toxicology. However, despite the quite optimistic and bright future for these current procedures, a number of issues and problems remain. Therefore, efforts to develop new technologies and to refine current methods and approaches continue to challenge many laboratories worldwide.

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Cellular localization of cytochrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway

Cited by 58 publications

References 42 publications

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Structure of and energy reserves in the liver of wild and cultured yellowtail flounder, Limanda ferruginea

The versatile, changing, and advancing roles of fish in sediment toxicity assessment—a review

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