1995
DOI: 10.1159/000126823
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Cellular Mechanism of Melatonin Action in Neonatal Rat Pituitary

Abstract: Melatonin inhibits gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone (LH) release from neonatal rat anterior pituitary. Melatonin has been shown to decrease the concentration of several second messengers in neonatal pituitary, but it is not known which of them transduces the melatonin effect on LH release. In order to determine the mechanism of melatonin action, we tested the effect of melatonin on GnRH-induced LH release in the presence of specific drugs affecting second messengers. The calciu… Show more

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Cited by 18 publications
(21 citation statements)
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“…Three molecular structure–based subtypes of the melatonin receptors have been described: Mel 1A , or MT1 (expressed in mammalian and bird brain); Mel 1B , or MT2 (expressed mainly in mammalian retina); and Mel 1C , or MT3 (found in amphibian melanophores, brain, and retina, as well as in bird and fish brain) 9 . Melatonin receptors regulate several second messengers: cAMP, cGMP, diacylglycerol, inositol trisphosphate, arachidonic acid, and intracellular Ca 2+ concentration ([Ca 2+ ] i ) 8 …”
Section: Introductionmentioning
confidence: 99%
“…Three molecular structure–based subtypes of the melatonin receptors have been described: Mel 1A , or MT1 (expressed in mammalian and bird brain); Mel 1B , or MT2 (expressed mainly in mammalian retina); and Mel 1C , or MT3 (found in amphibian melanophores, brain, and retina, as well as in bird and fish brain) 9 . Melatonin receptors regulate several second messengers: cAMP, cGMP, diacylglycerol, inositol trisphosphate, arachidonic acid, and intracellular Ca 2+ concentration ([Ca 2+ ] i ) 8 …”
Section: Introductionmentioning
confidence: 99%
“…Melatonin is the hormone of the pineal gland responsible for the regulation of diurnal and seasonal activity rhythms in animals (Vanecek, 1998). The action of the pineal gland hormone requires the activity of specific receptors located primarily in the brain and in the peripheral tissues (Vanecek, 1998).…”
mentioning
confidence: 99%
“…The action of the pineal gland hormone requires the activity of specific receptors located primarily in the brain and in the peripheral tissues (Vanecek, 1998). For this reason melatonin may affect -directly or indirectly -the metabolism of a given organism (Vanecek, 1998;Maćkowiak et al, 1999a, b).…”
mentioning
confidence: 99%
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“…The membrane receptors (Mel 1a and Mel 1b ) are found primarily in the brain and may inhibit hormone-responsive cancers by inhibiting steroid hormone production. For example, activation of the membrane-bound receptors inhibits cAMP production and calcium influx and may inhibit release of GnRH from the hypothalamus [18,43], and luteinizing hormone and folliclestimulating hormone from the pituitary as well as prolactin release [19,44,45]. Subsequent downregulation of the release of these hormones by melatonin would affect 17β-estradiol production and may attenuate proliferation of estrogen-responsive cancers during the promotional phase, as hypothesized by Stevens and Davis [8] and reported by Blask et al [46].…”
Section: Membrane Receptorsmentioning
confidence: 89%