Cellular mechanisms of airway smooth muscle relaxant effects of anesthetic agents

Yamakage, Michiaki; Namiki, Akiyoshi

doi:10.1007/s00540-003-0194-4

Cited by 11 publications

(11 citation statements)

References 39 publications

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“…In rats and humans, acetylcholine released from parasympathetic nerve terminals is recognized as the most critical bronchoactive pathway in the airways [9]. The results derived from in vitro studies on the effects of local anesthetics on airways are conflicting.…”

mentioning

confidence: 98%

“…The results supported the hypothesis that interaction with the muscarinic M2 receptor-mediated signaling pathway might contribute to relaxation. Another possible explanation may be an effect on calcium mobilization [9]. In porcine preparations, lidocaine inhibited both the acetylcholine-induced increase in calcium sensitivity of the contractile apparatus and the release of muscarinic M3 receptor-mediated intracellular calcium [12].…”

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confidence: 99%

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Effects of levobupivacaine on isolated rat tracheal smooth muscle

et al. 2015

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Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on isolated rat tracheal smooth muscle. A portion of rat trachea 5 mm in length was mounted in 30 ml of Krebs solution in a muscle bath at 37 °C. The following effects of levobupivacaine were assessed: (1) the effect on tracheal smooth muscle resting tension (n = 6), (2) the effect on contraction caused by 10(-6) M methacholine (n = 6) and (3) the effect on electrically induced tracheal smooth muscle contractions (n = 6). Levobupivacaine caused dose-dependent relaxation in the trachealis muscle precontracted with 10(-6) M methacholine. Contraction inhibition was statistically significant when 10(-5) and 10(-4) M levobupivacaine were applied, compared with the contraction inhibition that occurred in the control groups (p < 0.01). A high dose of levobupivacaine also decreased the spike contraction induced by electrical field stimulation. This study indicated that high concentrations of levobupivacaine might antagonize the cholinergic receptors and inhibit parasympathetic function of the trachea.

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confidence: 98%

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confidence: 99%

Effects of levobupivacaine on isolated rat tracheal smooth muscle

et al. 2015

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“…To increase safety in asthma and COPD patients, the anesthesiologist must take an adequate medical history and, when preoperative intervention is indicated, obtain early consultation and appropriate treatment. Preoperative evaluation of the patient includes: (1) activities of daily living (ADL) and physical status; (2) presence of infectious symptoms; (3) amount and purulence of sputum; (4) presence of allergies; (5) factors known to trigger attacks or exacerbations; (6) use and effectiveness of medications; (7) presence of late evening or early morning symptoms; (8) responses to cold air, house dust, and cigarette smoke; (9) previous history of surgery and anesthesia; (10) coexisting disorders (e.g., ischemic heart disease, renal failure, diabetes mellitus, neuromuscular disease); and (11) obesity or sleep apnea syndrome [1,2,32]. The GOLD 2006 guidelines emphasize that COPD not only involves the lungs but also represents a systemic infl ammatory disorder [2].…”

Section: Preoperative Evaluationmentioning

confidence: 99%

“…The contraction of airway smooth muscle is regulated by acetylcholine released from vagal nerves, catecholamines released by the adrenal glands, and histamine derived from mast cells [8]. Acetylcholine released by vagal stimulation binds with muscarinic receptors (mAChR) in airway smooth muscle.…”

Section: Inhibition Of Increased Intracellular Ca 2+ Concentrations Imentioning

confidence: 99%

“…Inhalational anesthetics Inhalational anesthetics have inherent bronchodilator effects [6][7][8]. These effects are mediated by the regulation of voltage-dependent calcium channel activity, by an increase in intracellular cyclic (c) AMP via beta receptors, and by a decrease in intracellular Ca 2+ concentrations, leading to the relaxation of smooth muscle.…”

Section: Choice Of Anestheticsmentioning

confidence: 99%

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Guideline-oriented perioperative management of patients with bronchial asthma and chronic obstructive pulmonary disease

2008

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Increased airway hyperresponsiveness is a major concern in the perioperative management of patients with bronchial asthma and chronic obstructive pulmonary disease. Guidelines using evidence-based medicine are continually being updated and published regarding the diagnosis, treatment, and prevention of these respiratory disorders. Perioperative management in these patients involves: (1) adequate control of airway hyperresponsiveness, including detection of purulent sputum and infection before surgery; (2) evidence-based control of anesthesia; and (3) the aggressive use of beta-2 adrenergic stimulants and the systemic administration of steroids for the treatment of acute attacks. Good preoperative control, including the use of leukotriene antagonists, can reduce the incidence of life-threatening perioperative complications. Awareness of recent guidelines is thus important in the management of patients with airway hyperresponsiveness. This review covers the most recent guidelines for the perioperative management of patients with bronchial asthma and chronic obstructive pulmonary disease.

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The Respiratory System

Robinson¹

2009

Equine Anesthesia

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Cellular mechanisms of airway smooth muscle relaxant effects of anesthetic agents

Cited by 11 publications

References 39 publications

Effects of levobupivacaine on isolated rat tracheal smooth muscle

Effects of levobupivacaine on isolated rat tracheal smooth muscle

Guideline-oriented perioperative management of patients with bronchial asthma and chronic obstructive pulmonary disease

The Respiratory System

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