Cellular mechanisms of contextual fear memory reconsolidation: Role of hippocampal SFKs, TrkB receptors and GluN2B-containing NMDA receptors

Nachtigall, Eduarda G.; de C. Myskiw, Jociane; Izquierdo, Ivan; Furini, Cristiane R. G.

doi:10.1007/s00213-023-06463-y

Cited by 4 publications

References 138 publications

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Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

Hoisington,

Gangal,

Phamluong

et al. 2024

Preprint

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Prosapip1 is a brain-specific protein localized to the postsynaptic density, where it promotes dendritic spine maturation in primary hippocampal neurons. However, nothing is known about the role of Prosapip1in vivo. To examine this, we utilized the Cre-loxP system to develop a Prosapip1 neuronal knockout mouse. We found that Prosapip1 controls the synaptic localization of its binding partner SPAR, along with PSD-95 and the GluN2B subunit of the NMDA receptor (NMDAR) in the dorsal hippocampus (dHP). We next sought to identify the potential contribution of Prosapip1 to the activity and function of the NMDAR and found that Prosapip1 plays an important role in NMDAR-mediated transmission and long-term potentiation (LTP) in the CA1 region of the dHP. As LTP is the cellular hallmark of learning and memory, we examined the consequences of neuronal knockout of Prosapip1 on dHP-dependent memory. We found that global or dHP-specific neuronal knockout of Prosapip1 caused a deficit in learning and memory whereas developmental, locomotor, and anxiety phenotypes were normal. Taken together, Prosapip1 in the dHP promotes the proper localization of synaptic proteins which, in turn, facilitates LTP driving recognition, social, and spatial learning and memory.

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Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

Hoisington,

Gangal,

Phamluong

et al. 2024

Preprint

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Central neurophysiological mechanisms of stress resistance in post-traumatic stress disorder

Kondashevskaya,

Artemyeva,

Aleksankina

2024

Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

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Post-traumatic stress disorder (PTSD) is a severe, disabling syndrome that is induced by an extremely powerful negative impact on the people’s psyche. Symptoms of the disease most often do not appear in the entire population of stressed people and not immediately, but after some indefinite period of time. The disease is caused by central, genetic, epigenetic and neurobiological determinants, interactively integrated within the underlying social and natural-anthropogenic context. The simultaneous development of a pathological reaction from the hypothalamic-pituitary-adrenal, sympathoadrenal and immune systems was established. Information on the state of the main biogenic and amino acid neurotransmitters of the central nervous system in PTSD is presented. Researchers are currently focusing on peptide hormones such as brain-derived neurotrophic factor, neuropeptide Y, and leptin, which can be used to diagnose and treat PTSD. An analysis of the literature led to the conclusion that about the characteristics of stress-resistant people and animals very little is still known.

show abstract

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

Hoisington,

Gangal,

Phamluong

et al. 2024

Preprint

View full text Add to dashboard Cite

Prosapip1 is a brain-specific protein localized to the postsynaptic density, where it promotes dendritic spine maturation in primary hippocampal neurons. However, nothing is known about the role of Prosapip1 in vivo . To examine this, we utilized the Cre-loxP system to develop a Prosapip1 neuronal knockout mouse. We found that Prosapip1 controls the synaptic localization of its binding partner SPAR, along with PSD-95 and the GluN2B subunit of the NMDA receptor (NMDAR) in the dorsal hippocampus (dHP). We next sought to identify the potential contribution of Prosapip1 to the activity and function of the NMDAR and found that Prosapip1 plays an important role in NMDAR-mediated transmission and long-term potentiation (LTP) in the CA1 region of the dHP. As LTP is the cellular hallmark of learning and memory, we examined the consequences of neuronal knockout of Prosapip1 on dHP-dependent memory. We found that global or dHP-specific neuronal knockout of Prosapip1 caused a deficit in learning and memory whereas developmental, locomotor, and anxiety phenotypes were normal. Taken together, Prosapip1 in the dHP promotes the proper localization of synaptic proteins which, in turn, facilitates LTP driving recognition, social, and spatial learning and memory.

show abstract

Cellular mechanisms of contextual fear memory reconsolidation: Role of hippocampal SFKs, TrkB receptors and GluN2B-containing NMDA receptors

Cited by 4 publications

References 138 publications

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

Central neurophysiological mechanisms of stress resistance in post-traumatic stress disorder

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

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