Cellular Mechanisms of Rejection and Regeneration in Peripheral Nerve Allografts

Lassner, Franz; Schaller, E.; Steinhoff, Gustav; Wonigeit, K.; Walter, G. F.; Berger, A.

doi:10.1097/00007890-198909000-00006

Cited by 77 publications

(53 citation statements)

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“…It effectively cleared the immunogenicity of the xenogenous nerve, and meanwhile preserved Schwann cell basilar membrane and the integrity of its organizational structure. The results in this study showed that the transplanted nerve in the B group had a good continuity without cicatricial adhesion to the surrounding tissues nor shedding or isolation and no obvious inflammatory reaction occurred to the surrounding tissues at 16 w after operation (the result is consistent to those reported (Lassner et al, 1989;Sondell et can serve as a nerve graft substitute with low antigenicity. This overcomes the obstacle posed by immunologic rejections to grafts in clinical practice.…”

Section: Discussionsupporting

confidence: 87%

Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury

Zhang

Zhang²,

Liu³

et al. 2013

Int. J. Morphol.

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SUMMARY:This work aims to investigate the effect of fetal amnion-wrapped acellular allogenic nerve transplantation on peripheral nerve injury (PNI) in dogs and to explore its advantages and feasibility in PNI repair. A total of 15 dogs were divided into three groups: the allogenic nerve transplantation (A), amnion-wrapped allogenic nerve transplantation (B), and allogenic nerve donor (C) groups. Neurite counts after myelin and H-E stainings, soleus muscle action potentials, and sciatic nerve conductive velocities were compared between the A and B groups at 16 w after operation. The B group showed better nerve regeneration than the A group at 16 w. Compared with the A group, the B group showed a better growth continuity of the transplanted nerve and milder inflammatory reactions around the nerve. The B group presented much more proliferated Schwannocytes and regenerated nerve fibers than the A group. The neurite density and the amplitude of the soleus muscle action potentials in the B group were significantly higher than those in the A group (P < 0.05). The two groups did not show significant differences in nerve conductive velocities (P > 0.05). Amnion-wrapped acellular allogenic nerve transplantation can improve defected nerve morphology and the quality of transplanted nerve regeneration.

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Section: Discussionsupporting

confidence: 87%

Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury

Zhang

Zhang²,

Liu³

et al. 2013

Int. J. Morphol.

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show abstract

“…On the other hand, they have some drawbacks such as sensation at the donor site, creating a second incision in the body, and having a limited supply of the donor site. Cadaveric nerve allografts are another option as nerve grafts, which do not require a second incision on the patient, however, compel systemic immunosuppression (Trumble and Shon 2000 ;Pollard et al 1971 ;Mackinnon et al 1982 ;Lassner et al 1989 ;Gulati and Cole 1990 ;Gulati 1998 ). This technique is usually preferred in cases like severely damaged segmental nerve loss (Ray and Mackinnon 2010 ).…”

Section: Biomaterials Design For Peripheral Nerve Repairmentioning

confidence: 99%

Bioactive Nanomaterials for Neural Engineering

et al. 2016

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“…Se sabe que las células de Schwann colaboran activamente en la resorción de las fibras de mielina, al adquirir una actividad fagocítica, ayudando a suprimir los restos en la zona lesionada (Lassner et al, 1989;Yao et al, 2013 (Ide et al, 1983;Howard et al, 2013). Esto se ha demostrado con un segmento de nervio periférico que se congela y se descongela, de manera que las células de Schwann se mueren, pero la lámina basal que las rodea permanece intacta.…”

Section: Histología De La Degeneración Wallerinaunclassified