Cellular Mechanisms of Resolution of Drusen After Laser Coagulation

Duvall, Josephine; Tso, Mark O.M.

doi:10.1001/archopht.1985.01050050086024

Cited by 88 publications

(25 citation statements)

References 22 publications

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“…[46][47][48][49][50] It has been suggested that macrophages play a role in removal of drusen and other waste products, perhaps preventing the severe end-stage pathology that can occur after the accumulation of these deposits. 51,52 Monocyte chemotactic protein-1 (MCP-1/CCL2) is a chemokine that directs monocyte recruitment into inflamed tissues. 53 Mice deficient for this protein, especially when also deficient for the chemokine receptor CX3CR1, were reported to exhibit drusen-like deposits, suggesting that impaired macrophage recruitment results in reduced clearance of debris from Bruch's membrane.…”

Section: How Might Macrophages Promote Macular Degeneration?mentioning

confidence: 45%

Macrophages in neovascular age-related macular degeneration: friends or foes?

Skeie

Mullins

2008

Eye

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The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this paper, we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.

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Section: How Might Macrophages Promote Macular Degeneration?mentioning

confidence: 45%

Macrophages in neovascular age-related macular degeneration: friends or foes?

Skeie

Mullins

2008

Eye

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“…The only advocated treatment of ARM is laser photocoagulation for specified cases with RPE detachment or choroidal neovascular membranes (Grey et al 1979 Early intervention through either prevention or treatment of drusen (Gass 1973;Duvall & Tso 1985) will require detailed knowledge of pre-exudative phases of ARM.…”

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confidence: 45%

Image analysis of changes in drusen area

Sébag

Peli

Lahav

1991

Acta Ophthalmologica

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Computerized image processing was used to analyze color fundus photographs of 11 patients (22 eyes) with macular drusen who were followed for more than 2 years (mean follow-up, 4.7 years). Significant changes over time (more than +/- 20% of baseline area) were measured in the surface area of macular drusen in 18 of 22 (82%) eyes. An increase in the drusen area was associated significantly with eyes with mostly hard drusen and an initially smaller drusen area; but a decrease was associated with eyes with mostly soft drusen and an initially larger drusen area (P less than 0.01). The mean absolute rate of change in the drusen area was more than twice as great in eyes with mostly soft drusen compared with those with mostly hard drusen (P less than 0.05). All eye pairs studied showed a concomitant increase or decrease in the drusen area.

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“…This concept was introduced with respect to the choroid when cellular processes from the choroidal pericytes were described in the inner portion of Bruch's membrane after photocoagulation of drusen. 24 It was suggested that they may play a role in the resolution of drusen after laser treatment, and this process was likened to the phagocytic activity of mesangial cells in the glomerulus. 24 Endothelial cells may also undertake this function.…”

Section: Function Of Processesmentioning

confidence: 44%

Cytoarchitecture of Choroidal Capillary Endothelial Cells

Guymer

Bird

Hageman

2004

Invest. Ophthalmol. Vis. Sci.

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The finding of cellular processes of choroidal capillary endothelial cells penetrating their basal laminae is normal. These processes may serve to stabilize choroidal endothelial cells physically and play an important structural role in the maintenance of patency of the choriocapillaris. It is also possible that they have additional functions, as suggested for similar processes in other tissues. They are not necessarily the harbinger of choroidal neovascularization, although growth of new vessels may result from distortion of this normal attribute.

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Cellular Mechanisms of Resolution of Drusen After Laser Coagulation

Cited by 88 publications

References 22 publications

Macrophages in neovascular age-related macular degeneration: friends or foes?

Macrophages in neovascular age-related macular degeneration: friends or foes?

Image analysis of changes in drusen area

Cytoarchitecture of Choroidal Capillary Endothelial Cells

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