Cellular Pattern and Nerve Supply of the Human Organ of Corti: A Preliminary Report

Bredberg, Göran; Engström, Hans; Ades, Harlow W.

doi:10.1001/archotol.1965.00760010464003

Cited by 142 publications

(176 citation statements)

References 4 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…This finding is consistent with numerous prior reports indicating a large extent of variation in human cochlear length (Bredberg 1968;Ulehlova et al 1987;Wright et al 1987;Hardy 1968;Kawano et al 1996;Ketten et al 1998: Skinner et al 2002. We did not observe a significant difference between female and male OC length as reported by Sato et al (1991), who found OC lengths of 32.3 T 1.8 mm for females and 37.1 T 1.6 mm for males (total n = 18).…”

Section: Measurements Of Oc Sg and Mw And Implications For CIsupporting

confidence: 93%

“…In the basal coil, the nerve bundles from the OC take a relatively direct radial course into the modiolus, but in the middle and apical turns, the trajectory of the fibers deviates significantly because Rosenthal_s canal is much shorter than the OC and does not extend to the apical turn (Bredberg 1968;Glueckert et al 2005). Thus, represented frequency along the SG must be offset from that of the OC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frequency Map for the Human Cochlear Spiral Ganglion: Implications for Cochlear Implants

Stakhovskaya

Sridhar

Bonham

et al. 2007

JARO

356

357

View full text Add to dashboard Cite

The goals of this study were to derive a frequencyposition function for the human cochlear spiral ganglion (SG) to correlate represented frequency along the organ of Corti (OC) to location along the SG, to determine the range of individual variability, and to calculate an Baverage^frequency map (based on the trajectories of the dendrites of the SG cells). For both OC and SG frequency maps, a potentially important limitation is that accurate estimates of cochlear place frequency based upon the Greenwood function require knowledge of the total OC or SG length, which cannot be determined in most temporal bone and imaging studies. Therefore, an additional goal of this study was to evaluate a simple metric, basal coil diameter that might be utilized to estimate OC and SG length. Cadaver cochleae (n = 9) were fixed G24 h postmortem, stained with osmium tetroxide, microdissected, decalcified briefly, embedded in epoxy resin, and examined in surface preparations. In digital images, the OC and SG were measured, and the radial nerve fiber trajectories were traced to define a series of frequency-matched coordinates along the two structures. Images of the cochlear turns were reconstructed and measurements of basal turn diameter were made and correlated with OC and SG measurements. The data obtained provide a mathematical function for relating represented frequency along the OC to that of the SG.Results showed that whereas the distance along the OC that corresponds to a critical bandwidth is assumed to be constant throughout the cochlea, estimated critical band distance in the SG varies significantly along the spiral. Additional findings suggest that measurements of basal coil diameter in preoperative images may allow prediction of OC/SG length and estimation of the insertion depth required to reach specific angles of rotation and frequencies. Results also indicate that OC and SG percentage length expressed as a function of rotation angle from the round window is fairly constant across subjects. The implications of these findings for the design and surgical insertion of cochlear implants are discussed.

show abstract

Section: Measurements Of Oc Sg and Mw And Implications For CIsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Frequency Map for the Human Cochlear Spiral Ganglion: Implications for Cochlear Implants

Stakhovskaya

Sridhar

Bonham

et al. 2007

JARO

356

357

View full text Add to dashboard Cite

show abstract

“…It has been reported by KIMURA (1965), ENGSTROM (1966), BREDBERG (1968, KOSAKA et al (1971) andLIM (1972) that the sensory hair arrangements form the letter W or V in outer hair cells without kinocilia in the mature animals or the human adults. The present study showed that in the 22-week 2-day old fetus the sensory hairs of both inner and outer hair cells were arranged in the fashion similar to the adult ones (Fig.…”

Section: Discussionmentioning

confidence: 96%

Cochlea of the human fetus: A scanning electron microscope study.

Igarashi

1980

Arch. Histol. Jap., Arch. Histol. Jpn

View full text Add to dashboard Cite

“…In humans, degeneration of hair cells in the basalmost cochlea due to unknown causes begins at a very early age (Johnsson and Hawkins 1972) and progresses with increasing age (Bredberg 1968). This suggests that the basal organ of Corti in humans may be damaged by relatively mild noise exposures, as is the mouse ear (Wang et al 2002).…”

Section: Implications Of the Findingsmentioning

confidence: 99%

Immunocytochemical Traits of Type IV Fibrocytes and Their Possible Relations to Cochlear Function and Pathology

Adams

2009

JARO

View full text Add to dashboard Cite

One of the more consistent and least understood changes in the aging human cochlea is the progressive loss of fibrocytes within the spiral ligament. This report presents an animal model for type IV fibrocyte loss, along with immunocytochemical evidence that noise-induced loss of these cells may account for previously unexplained hearing losses. The remarkably low threshold for noise-induced loss of type IV fibrocytes, approximately 24 dB less than the threshold for adjacent hair cell destruction, may account for the prevalence of missing fibrocytes in humans. In mice, changes in the spectrum of traumatizing noise had little effect upon the site of loss of the fibrocytes, suggesting that the primary site of damage that induced the loss was the basal-most cochlear turn, a site expected to be damaged by all three noise bands. Type IV fibrocytes were found to immunostain for connective tissue growth factor (CTGF) and for transforming growth factor beta receptor 3, a receptor that is known to activate CTGF expression. Type IV fibrocytes lack immunostaining for adenosine triphosphatase and connexins that are key players in potassium ion uptake and transmission, which suggests that they play little, if any, role in potassium recycling from perilymphatic space to the endolymphatic space. Consequently, their loss probably does not directly reduce this process. Immunostaining for a receptor for CTGF, low-density-lipoprotein-related protein 1, indicated that CTGF acts as an autocrine and a paracrine agent within the cochlea. The lack of CTGF paracrine effects following noise-induced loss of type IV fibrocytes may account for previously unexplained hearing losses.

show abstract

Cellular Pattern and Nerve Supply of the Human Organ of Corti: A Preliminary Report

Cited by 142 publications

References 4 publications

Frequency Map for the Human Cochlear Spiral Ganglion: Implications for Cochlear Implants

Frequency Map for the Human Cochlear Spiral Ganglion: Implications for Cochlear Implants

Cochlea of the human fetus: A scanning electron microscope study.

Immunocytochemical Traits of Type IV Fibrocytes and Their Possible Relations to Cochlear Function and Pathology

Contact Info

Product

Resources

About