Cellular pattern formation during retinal regeneration: A role for homotypic control of cell fate acquisition

Tyler, Melinda J.; Cameron, David

doi:10.1016/j.visres.2006.08.025

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…models can be useful in helping to organize and prioritize the importance of various design criteria. [93][94][95][96][97][98] For example, models could provide insight into increasing conduit length demands, improving mass transport, and enhancing vascularization and cellular migration. Computational models could also be used to predict how these parameters change with varied diameter conduits and identify critical limitations.…”

Section: Critical Reviews™ In Biomedical Engineeringmentioning

confidence: 99%

Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges

Pfister

Gordon

Loverde

et al. 2011

Crit Rev Biomed Eng

311

269

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Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries, outcomes are often unsatisfactory following severe trauma. Nerve repair and regeneration presents unique clinical challenges and opportunities, and substantial contributions can be made through the informed application of biomedical engineering strategies. This article reviews the clinical presentations and classification of nerve injuries, in addition to the state of the art for surgical decision-making and repair strategies. This discussion presents specific challenges that must be addressed to realistically improve the treatment of nerve injuries and promote widespread recovery. In particular, nerve defects a few centimeters in length use a sensory nerve autograft as the standard technique; however, this approach is limited by the availability of donor nerve and comorbidity associated with additional surgery. Moreover, we currently have an inadequate ability to noninvasively assess the degree of nerve injury and to track axonal regeneration. As a result, wait-and-see surgical decisions can lead to undesirable and less successful "delayed" repair procedures. In this fight for time, degeneration of the distal nerve support structure and target progresses, ultimately blunting complete functional recovery. Thus, the most pressing challenges in peripheral nerve repair include the development of tissue-engineered nerve grafts that match or exceed the performance of autografts, the ability to noninvasively assess nerve damage and track axonal regeneration, and approaches to maintain the efficacy of the distal pathway and targets during the regenerative process. Biomedical engineering strategies can address these issues to substantially contribute at both the basic and applied levels, improving surgical management and functional recovery following severe peripheral nerve injury.

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Section: Critical Reviews™ In Biomedical Engineeringmentioning

confidence: 99%

Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges

Pfister

Gordon

Loverde

et al. 2011

Crit Rev Biomed Eng

311

269

View full text Add to dashboard Cite

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Ontogeny of cone photoreceptor mosaics in zebrafish

Allison

Barthel

Skebo

et al. 2010

J of Comparative Neurology

139

162

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Cone photoreceptors in fish are typically arranged into a precise, reiterated pattern known as a 'cone mosaic'. Cone mosaic patterns can vary in different fish species and in response to changes in habitat, yet their function and the mechanisms of their development remain speculative. Zebrafish (Danio rerio) have four cone subtypes arranged into precise rows in the adult retina.Here we describe larval zebrafish cone patterns and investigate a previously unrecognized transition between larval and adult cone mosaic patterns. Cone positions were determined in transgenic zebrafish, expressing green fluorescent protein (GFP) in their UV-sensitive cones, by the use of multiplex in situ hybridization labelling of various cone opsins. We developed a 'mosaic metric' statistical tool to measure local cone order. We found that ratios of the various cone subtypes in larval and adult zebrafish were statistically different. The cone photoreceptors in larvae form a regular heterotypic mosaic array, i.e. the position of any one cone spectral subtype relative to the other cone subtypes is statistically different from random. However, the cone spectral subtypes in larval zebrafish are not arranged in continuous rows as in the adult. We used cell birthdating to show that the larval cone mosaic pattern remains relatively disorganized, or perhaps is somewhat remodeled, within the adult retina. The abundance of cone subtypes relative to other subtypes is different in this larval remnant compared to that of larvae or canonical adult zebrafish retina. These observations provide baseline data for understanding the development of cone mosaics via comparative analysis of larval and adult cone development in a model species.

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Cellular pattern formation during retinal regeneration: A role for homotypic control of cell fate acquisition

Cited by 2 publications

References 57 publications

Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges

Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges

Ontogeny of cone photoreceptor mosaics in zebrafish

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