Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

Tay, J. S. H.; Levesque, Jean‐Pierre

doi:10.1007/s12185-016-2162-4

Cited by 84 publications

(71 citation statements)

References 112 publications

(157 reference statements)

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“…15 The BM is richly innervated with myelinated and nonmyelinated nerve fibers, with a close association between sympathetic nerve fiber endings and bone-lining osteoblasts, osteoclasts, and perivascular Nes-GFP + MSCs. 16 In steady state conditions, circadian noradrenaline secretion by the SNS in the perivascular HSC niche decreases CXCL12 expression by perivascular stromal cells, which results in the circadian release of HSCs from the BM niche and their subsequent mobilization into the bloodstream. 15,17 Sympathetic nerve fibers are sheathed by nonmyelinating Schwann cells that express not only Nes, but also HSC niche factor genes such as Cxcl12 and Scf (Kitl).…”

Section: Hematopoietic Stem Cells and Their Nichementioning

confidence: 99%

“…Injection of G-CSF leads to the decreased expression of these HSC retention factors, contributing to HSPC mobilization. 16 The administration of MSCs in a mouse model results in the downregulation of niche factors, including Cxcl12, Scf, and Vcam-1, in endosteal cells. These BM changes are similar to events that occur during G-CSF-induced HSPC mobilization.…”

Section: Mesenchymal Stromal Cellsmentioning

confidence: 99%

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Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Kruijf

Fibbe

Pel

2019

Annals of the New York Academy of Sciences

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Peripheral blood hematopoietic stem and progenitor cells (HSPCs), mobilized by granulocyte colony-stimulating factor, are widely used as a source for both autologous and allogeneic stem cell transplantation. The use of mobilized HSPCs has several advantages over traditional bone marrow-derived HSPCs, including a less invasive harvesting process for the donor, higher HSPC yields, and faster hematopoietic reconstitution in the recipient. For years, the mechanisms by which cytokines and other agents mobilize HSPCs from the bone marrow were not fully understood. The field of stem cell mobilization research has advanced significantly over the past decade, with major breakthroughs in the elucidation of the complex mechanisms that underlie stem cell mobilization. In this review, we provide an overview of the events that underlie HSPC mobilization and address the relevant cellular and molecular components of the bone marrow niche. Furthermore, current and future mobilizing agents will be discussed.

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Section: Hematopoietic Stem Cells and Their Nichementioning

confidence: 99%

Section: Mesenchymal Stromal Cellsmentioning

confidence: 99%

Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Kruijf

Fibbe

Pel

2019

Annals of the New York Academy of Sciences

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“…Since G-SCF stimulates β-adrenergic sympathetic nervous activity, this provides evidence for a signaling chain inducing HSPC mobilization. However, three recent studies in mice genetically altered by a conditional deletion of the CXCL12 or SCF genes in mature osteoblasts using Ocn-Cre or the 2.3-kb fragment of the rat collagen 1a (Col2.3)-Cre did not result in HSPC mobilization, but rather a restriction in B-cell lymphopoiesis [55,108,109], casting some doubt on the relevance of the above-mentioned gene regulation in this cell type [110]. On the other hand, in transgenic mice expressing the human diphtheria toxin receptor under the control of the Dmp1 gene promoter, treatment with diphtheria toxin which kills osteocytes in these mice, abolished HSPC mobilization in response to G-CSF [111].…”

Section: Osteoblastic Cellsmentioning

confidence: 99%

Current Developments in Mobilization of Hematopoietic Stem and Progenitor Cells and Their Interaction with Niches in Bone Marrow

Richter

Forssmann

Henschler

2017

Transfus Med Hemother

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The clinical application of hematopoietic stem and progenitor cells (HSPCs) has evolved from a highly experimental stage in the 1980s to a currently clinically established treatment for more than 20,000 patients annually who suffer from hematological malignancies and other severe diseases. Studies in numerous murine models have demonstrated that HSPCs reside in distinct niches within the bone marrow environment. Whereas transplanted HSPCs travel through the bloodstream and home to sites of hematopoiesis, HSPCs can be mobilized from these niches into the blood either physiologically or induced by pharmaceutical drugs. Firstly, this review aims to give a synopsis of milestones defining niches and mobilization pathways for HSPCs, including the identification of several cell types involved such as osteoblasts, adventitial reticular cells, endothelial cells, monocytic cells, and granulocytic cells. The main factors that anchor HSPCs in the niche, and/or induce their quiescence are vascular cell adhesion molecule(VCAM)-1, CD44, hematopoietic growth factors, e.g. stem cell factor (SCF) and FLT3 Ligand, chemokines including CXCL12, growth-regulated protein beta and IL-8, proteases, peptides, and other chemical transmitters such as nucleotides. In the second part of the review, we revise the current understanding of HSPC mobilization. Here, we discuss which mechanisms found to be active in HSPC mobilization correspond to the mechanisms relevant for HSPC interaction with niche cells, but also deal with other mediators and signals that target individual cell types and receptors to mobilize HSPCs. A multitude of questions remain to be addressed for a better understanding of HSPC biology and its implications for therapy, including more comprehensive concepts for regulatory circuits such as calcium homeostasis and parathormone, metabolic regulation such as by leptin, the significance of autonomic nervous system, the consequences of alteration of niches in aged patients, or the identification of more easily accessible markers to better predict the efficiency of HSPC mobilization.

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“…During mobilization, hematopoiesis is enhanced, and large numbers of cells are released from the BM to the blood, including stem and immature hematopoietic cells (Lapidot & Petit, 2002). Mechanism of mobilization is complex and involves several cell populations and cytokine pathways (Duhrsen et al, 1988;Lapidot & Petit, 2002;Tay et al, 2017), with G-CSF (granulocyte colony-stimulating factor) as one of the best characterized mobilizing factors (Souza et al, 1986;Lapid et al, 2008). G-CSF acts on the BM myeloid progenitors, driving their proliferation and differentiation toward granulocytes (Metcalf & Nicola, 1983).…”

Section: Introductionmentioning

confidence: 99%

Cobalt protoporphyrin IX increases endogenous G‐ CSF and mobilizes HSC and granulocytes to the blood

Szade

Nowak

et al. 2019

EMBO Mol Med

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Granulocyte colony‐stimulating factor (G‐CSF) is used in clinical practice to mobilize cells from the bone marrow to the blood; however, it is not always effective. We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G‐CSF, IL‐6, and MCP‐1 in mice, triggering the mobilization of granulocytes and hematopoietic stem and progenitor cells (HSPC). Compared with recombinant G‐CSF, CoPP mobilizes higher number of HSPC and mature granulocytes. In contrast to G‐CSF, CoPP does not increase the number of circulating T cells. Transplantation of CoPP‐mobilized peripheral blood mononuclear cells (PBMC) results in higher chimerism and faster hematopoietic reconstitution than transplantation of PBMC mobilized by G‐CSF. Although CoPP is used to activate Nrf2/HO‐1 axis, the observed effects are Nrf2/HO‐1 independent. Concluding, CoPP increases expression of mobilization‐related cytokines and has superior mobilizing efficiency compared with recombinant G‐CSF. This observation could lead to the development of new strategies for the treatment of neutropenia and HSPC transplantation.

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Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

Cited by 84 publications

References 112 publications

Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Current Developments in Mobilization of Hematopoietic Stem and Progenitor Cells and Their Interaction with Niches in Bone Marrow

Cobalt protoporphyrin IX increases endogenous G‐ CSF and mobilizes HSC and granulocytes to the blood

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