Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis

Zhao, Zhengdong; Liu, Xiaozhou; Zong, Yanjun; Shi, Xinyu; Sun, Yu

doi:10.3390/v16010012

Cited by 2 publications

(1 citation statement)

References 126 publications

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“…Notably, this study strengthened the evidence that infectious agents, particularly viruses of the Herpesviridae family and SARS-CoV-2, contribute to the occurrence of a nonnegligible number of cases of SSNHL in adults [ 33 , 34 ], as was previously widely described for the pediatric population [ 35 , 36 , 37 , 38 ]. These viruses were also found to be the most common known cause of labyrinthitis, confirming the main etiopathogenetic hypotheses in the current literature [ 38 , 39 ]. Viral infections might induce SSNHL through different mechanisms within the inner ear, such as direct invasion, reactivation of a latent virus, immune-mediated injuries, or abnormal stress responses [ 34 , 40 ].…”

Section: Discussionsupporting

confidence: 82%

Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years

Aldè,

Ambrosetti,

Piatti

et al. 2024

JCM

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Objectives: The purpose of this study was to investigate the hearing characteristics and causes of sudden sensorineural hearing loss (SSNHL) in patients aged from 15 to 40 years, focusing on audiological outcomes one year after the diagnosis. Methods: The medical records of individuals with SSNHL who were referred to our tertiary-level audiologic center were reviewed. All patients had undergone comprehensive diagnostic evaluations, including high-resolution 3D-FLAIR delayed magnetic resonance imaging (MRI), cone beam computed tomography (CBCT), and screening for coagulation, infectious, and autoimmune diseases. Results: Overall, 56 patients (mean age 28.1 ± 7.6 years) were included in the study. The hearing threshold in the affected ear improved significantly from 56.0 ± 18.0 dB at the diagnosis to 46.9 ± 22.3 dB after one year (p = 0.02). The degree of hearing loss, audiometric configurations, hearing improvements, and adherence to hearing treatments showed considerable variability among patients. Aural fullness, tinnitus, and hyperacusis were the predominant symptoms associated with SSNHL, and their prevalence decreased significantly over time. The diagnostic protocol led to the identification of the specific cause of SSNHL in 75% (42/56) of patients. The known etiology was found to be otological (39.3%), infectious (21.4%), autoimmune (7.1%), vascular (5.4%), or neoplastic (1.8%). In particular, Menière’s disease (n = 12), isolated cochlear endolymphatic hydrops (n = 6), HSV-1 (n = 5), and EBV (n = 4) infections were the most frequent causes of SSNHL. Conclusions: The identification of the specific etiology of SSNHL may facilitate a more personalized approach to management and treatment.

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Section: Discussionsupporting

confidence: 82%

Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years

Aldè,

Ambrosetti,

Piatti

et al. 2024

JCM

View full text Add to dashboard Cite

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Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

Alshehri,

Alahmari

2024

Medicine

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The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has manifested with respiratory symptoms and a spectrum of extra-pulmonary complications. Emerging evidence suggests potential impacts on the auditory and vestibular systems, but the extent and nature of these effects in recovered individuals remain unclear. This study aimed to investigate the prevalence and severity of vertigo and hearing impairment in individuals who have recovered from COVID-19 and to identify potential risk factors associated with these sensory symptoms. A cohort of 250 recovered COVID-19 patients was assessed. Standardized questionnaires, including the Dizziness Handicap Inventory and the Vertigo Symptom Scale, were used to evaluate vertigo. Hearing assessment was conducted using pure-tone audiometry, speech audiometry, tympanometry, and oto-acoustic emissions testing. Logistic regression analysis was performed to assess the association between COVID-19 severity and the occurrence of sensory symptoms, controlling for confounding variables such as age and comorbidities. Of the participants, 10% reported vertigo, varying severity. Hearing assessments revealed that most participants had normal hearing, with an average speech discrimination score of 94.6. Logistic regression analysis indicated a significant association between severe COVID-19 and an increased likelihood of vertigo (OR 2.11, 95% CI 1.02–4.35, P = .043) and hearing impairment (OR 3.29, 95% CI 1.60–6.78, P = .002). This study suggests a significant association between COVID-19 severity and vertigo and hearing impairment prevalence. The findings underscore the importance of sensory symptom assessment in the post-recovery phase of COVID-19, highlighting the need for comprehensive healthcare approaches to manage long-term sequelae.

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Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis

Cited by 2 publications

References 126 publications

Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years

Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years

Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

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