Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist-treated uterine leiomyomas

Vu, K.; Greenspan, David L.; Wu, Ting; Zacur, Howard A.; Kurman, Robert J.

doi:10.1016/s0046-8177(98)90116-2

Cited by 58 publications

(33 citation statements)

References 27 publications

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“…The immunohistochemical features found in this neoplasm are similar to those descrited for uterine leiomyoma in women, where large numbers receptors for estrogen and progesterone have been observed (Brandon et al, 1995;Vu et al, 1998;Ichimura et al, 1998) and there is an inverse correlation between the density of these receptors and markers of the proliferative activity of the cells (Mittal and Demopoulos, 2001).Other reports have also demonstrated the occurrence of estrogen receptors in rat vascular endothelium associated with uterine lyomyomas (Andersson et al, 2001), similar to those observed in the current report. Estrogen is thought to induce angiogenesis by inducing the synthesis and expression of the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and of nitric oxide, a potent vasodilator (Li et al, 2002;Rubanyi et al, 2002).…”

supporting

confidence: 90%

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Uterine leiomyoma in chimpanzee (Pan troglodytes)

Silva¹,

Ocarino²,

Cassali³

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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supporting

confidence: 90%

“…However, the molecular mechanism of action of those hormones is not well elucidated (Maruo et al, 2000). Estrogen is considered the largest promoter of neoplastic growth, but researches demonstrated that progesterone also stimulates the mitotic activity myometrial cells (Vu et al, 1998).…”

mentioning

confidence: 99%

Uterine leiomyoma in chimpanzee (Pan troglodytes)

Silva¹,

Ocarino²,

Cassali³

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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“…It has been suggested that the control of growth is regulated differently in the myometrium and leiomyomas and that the proliferative activity in leiomyomas is stimulated by progesterone [6,11]. The concept of hormonal control of proliferative activity is supported by the findings that the menopause and GnRHa therapy greatly reduce the number of mitotic cells [11][12][13]. In leiomyomas, the apoptotic index was significantly higher in the peripheral parts than in the central parts during the proliferative phase.…”

Section: Discussionmentioning

confidence: 99%

Different Proliferative and Apoptotic Activity in Peripheral versus Central Parts of Human Uterine Leiomyomas

Bourlev¹,

Pavlovitch²,

Stygar³

et al. 2003

Gynecol Obstet Invest

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Objective: To determine whether there are differences in proliferative and apoptotic activity and in expression of sex steroid receptors between central and peripheral parts of human uterine leiomyomas in different menstrual cycle phases. Methods: Biopsy specimens of the myometrium and peripheral and central parts of uterine leiomyomas were obtained from 15 women in the proliferative phase and 8 women in the secretory phase. Mitotic cells were detected by immunohistochemical staining for Ki67. Apoptotic cells were detected by the TUNEL method. Mitotic and apoptotic indexes were calculated. Tissue levels of oestrogen and progesterone receptors were measured using a commercial monoclonal receptor enzyme immunoassay kit. Results: During the secretory phase the mitotic index was significantly higher in the peripheral than in the central parts of the leiomyomas. During the proliferative phase the apoptotic index was significantly higher in the peripheral compared with the central parts. These differences were not reflected by differences in receptor expression. Conclusions: The results of this study suggest that the growth of a human uterine leiomyoma mainly occurs in the peripheral parts of the tumour, during the secretory phase of the menstrual cycle. The findings emphasise the importance of being consistent when taking samples for research work.

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“…The hypoestrogenic state induced by these agents results in reduction in size of the uterus itself as well as many of the fibroids in the majority of patients. A variety of theories have been proposed for the pathophysiologic mechanism leading to this shrinkage of fibroids, including a reduction in uterine arterial blood flow (Shaw 1989), a combination of ischemic injury and cellular atrophy (Colgan et al 1993), a reduction in cellularity (Upadhyaya et al 1990), apoptosis (Higashijima et al 1996), and a reduction in the number of cycling cells secondary to reduced levels of ER and PR (Robboy et al 2000;Vu et al 1998).…”

Section: Clinical Observationsmentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

496

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist-treated uterine leiomyomas

Cited by 58 publications

References 27 publications

Uterine leiomyoma in chimpanzee (Pan troglodytes)

Uterine leiomyoma in chimpanzee (Pan troglodytes)

Different Proliferative and Apoptotic Activity in Peripheral versus Central Parts of Human Uterine Leiomyomas

Etiology and pathogenesis of uterine leiomyomas: a review.

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