Cellular Proliferation in Villi of Normal and Pathological Pregnancies

Hustin, J.; Foidart, Jean‐Michel; Lambotte, R

doi:10.1159/000299115

Cited by 27 publications

(5 citation statements)

References 15 publications

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“…These villous haemorrhages are often confused with chorangiosis grade 111. In preeclampsia cases, especially when IUGR was superimposed, villous capillary endothelial cell proliferation was not achieved (Hustin et al 1984). By ultrastructural observation of chorangioma, proliferation of endothelial cell with an elongated nucleus lining the capillary lumen was found .…”

Section: Discussionmentioning

confidence: 95%

Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan

Soma¹,

Watanabe²,

Hata³

1995

Reprod. Fertil. Dev.

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It has been reported that both chorangiosis and chorangioma are increased in placentas at high altitudes. In this study, 1.14% of 2448 Japanese placentas obtained at 30-300 m had chorangiosis or chorangioma, compared with 3.24% of the Nepalese placentas (1300-3000 m) and 9.09% of the Tibetan samples (3800-4200 m). The incidence of both pathologies was significantly higher in the Himalayan groups than those of the Japanese group (P < 0.05). Obstetric complications of the 28 Japanese placentas with chorangiosis and chorangioma included Caesarean section 16 (57.1%), abruptio placentae 2 (7.14%), intrauterine growth retardation 3 (10.7%), intrauterine fetal death 4 (14.2%) and placenta praevia 4 (14.2%). Four infants (14.2%) had Apgar scores ranging from 0 to 3. Among 48 Himalayan placentas with chorangiosis and chorangioma, incidence of marked subchorionic fibrin was significantly higher (25%) than in the Japanese group (3.57%) (P < 0.05). The incidence of abnormal insertion of the cord was significantly higher (14.2%) in the Japanese group than in the Himalayan group (5%) (P < 0.05). There was no significant difference in the frequencies of intervillous thrombosis and infarction between the two groups. These findings suggest that the incidence of pathological change such as chorangiosis and chorangioma may be increased in placentas at Himalayan altitudes.

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Section: Discussionmentioning

confidence: 95%

Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan

Soma¹,

Watanabe²,

Hata³

1995

Reprod. Fertil. Dev.

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“…Specifically, a large proportion of the CTBs expressed these antigens compared with the same subpopulation in either the late second trimester of normal pregnancy or in nPTB. Thus, sPE is associated with morphological and molecular alterations in the CTB layer of the smooth chorion that were reminiscent of the villous immaturity involving the chorion frondosum that was noted many years ago ( Hustin et al, 1984 ).…”

Section: Discussionmentioning

confidence: 99%

Severe preeclampsia is associated with alterations in cytotrophoblasts of the smooth chorion

et al. 2017

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Pre-eclampsia (PE), which affects ∼8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related increase in production of PAPPA1, which releases IGF1 from its binding protein. IGF1 enhanced proliferation of smooth chorion CTBs, a possible explanation for expansion of this layer, which may partially compensate for the placental deficits.

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“…There is also molecular biological evidence of changes in placental angiogenesis in diabetes. In diabetic placentas, higher mitotic activity of endothelial cells was found in a study of incorporation of tritiated thymidine [14]. Biologically active basic fibroblast growth factor (bFGF), a member of the family of FGFs, is released by the first-trimester human trophoblast and works as an important angiogenic factor in that period [15].…”

Section: Introductionmentioning

confidence: 99%

Topological Properties and Spatial Organization of Villous Capillaries in Normal and Diabetic Placentas

et al. 2002

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Spatial arrangement and complexity of the capillary bed of placental terminal villi were analyzed in 9 normal and 11 diabetic placentas. Specimens were taken by systematic random sampling, fixed and stained in toto, and embedded in paraffin. Fifteen fields of view were sampled systematically from 120-µm-thick sections of specimens and examined using a confocal laser scanning microscope. Series of thin optical sections of terminal villi and their developmental forms were recorded by the confocal microscope and used as initial data for three-dimensional visualization of the spatial arrangement of villous capillaries. Vascular topology and branching were studied by focusing through the villus, making a schematic drawing of the villous capillary bed and counting redundant capillary connections. It was found that the basic arrangement of villous capillaries is similar in both normal and diabetic placentas. Nevertheless, the proportion of simple forms of the capillary bed without redundant connections is significantly higher in normal placentas and the mean number of redundant connections per villus is significantly higher in diabetic placentas. It is concluded that both the longitudinal growth and branching of capillaries contribute to the increase in the placental capillary bed in late gestation and that the capillary bed of diabetic villi is more complicated due to more intense capillary branching.

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Cellular Proliferation in Villi of Normal and Pathological Pregnancies

Cited by 27 publications

References 15 publications

Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan

Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan

Severe preeclampsia is associated with alterations in cytotrophoblasts of the smooth chorion

Topological Properties and Spatial Organization of Villous Capillaries in Normal and Diabetic Placentas

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