Cellular reaction on the anterior surface of 4 types of intraocular lenses

Müllner-Eidenböck, Andrea; Amon, Michael; Schauersberger, Jörg; Krüger, Andreas; Abela, Claudette; Petternel, Vanessa; Zidek, Thomas

doi:10.1016/s0886-3350(01)00846-x

Cited by 56 publications

(40 citation statements)

References 25 publications

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“…In the literature, PMMA IOLs are associated with the highest incidence of PCO. 1,2,4,8,33 A recent review 30 confirms that a polished IOL optic surface plays an important role in reducing LEC cell migration and adhesion to the lens optic. Hence, the submicrometric morphology and regularity of the IOL optic surface should be an additional factor in the migration and adhesion of LECs to the lens optic.…”

Section: Discussionmentioning

confidence: 96%

“…7 Therefore, inflammatory cells may contribute to the development of PCO by activating LEC migration and promoting the cells' differentiation and proliferation. 8 Many studies have examined how the biomaterial and surface properties of an IOL influence the inflammatory reaction following implantation as well as the adhesion and migration of LECs on the optic. 9-11 A sharp posterior optic edge design is considered a major factor in the prevention of PCO.…”

mentioning

confidence: 99%

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Analysis of intraocular lens surface properties with atomic force microscopy

Lombardo¹,

Santo²,

Lombardo³

et al. 2006

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Analysis of intraocular lens surface properties with atomic force microscopy

Lombardo¹,

Santo²,

Lombardo³

et al. 2006

Journal of Cataract and Refractive Surgery

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show abstract

“…Perhaps equally as important, however, in postoperative cellular reactions is IOL design [17]. Does IOL material play only a minor role in posterior chamber opacification while the design of the IOL is the major determinant?…”

Section: Discussionmentioning

confidence: 99%

Material Properties of Various Intraocular Lenses in an Experimental Study

et al. 2003

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Introduction: With the recent introduction of small-incision cataract surgery, requirements for intraocular lens (IOL) flexibility, strength and hydrophilicity have rapidly evolved. The IOL surface, however, remains a critical factor influencing uveal biocompatibility. Purpose: To objectively quantify factors of material properties of various IOLs using contact angle measurements, differential scanning calorimetry, dynamic-mechanical measurements and scanning electron microscopy. Material and Methods: In our study, 17 currently available IOLs were investigated using contact angle measurements to assess hydrophilicity and biocompatibility, as well as differential scanning calorimetry for the estimation of glass transition temperature. Mechanical capacity and flexibility were investigated using dynamic-mechanical measurements. Additional analysis of the IOL surface was performed using scanning electron microscopy. Results: The contact angle measurements of the studied IOLs revealed similar values within each group. The silicone IOLs had values between 106 and 119°. The PMMA IOLs were found to have a narrower range of values, between 73.2 and 75.5°. Lenses made of hydrogel had values between 59.2 and 69.1°. The heparin-modified surface showed the lowest contact angle of 56.5°. The glass transition temperature was determined by dynamic differential scanning calorimetry. The resulting values were between 118.8 and 113.5°C for PMMA IOLs, 15.5 and 14.0°C for acrylic IOLs, and –91.7 and –119.6°C for silicone IOLs. The dynamic-mechanical measurements revealed that PMMA lenses manifested characteristics similar to glass, whereas silicone lenses had characteristics similar to rubber. Acrylic lenses were between rubber and glass. Scanning electron microscopy revealed smooth dispersion of fibrin on hydrophobic IOLs and a relative lack of fibrin adhesion on hydrophilic materials. Conclusion: These results demonstrate that material properties of various IOL materials are consistent within classes of IOL materials. This suggests that the intraoperative and postoperative behavior of an IOL is predictable and related to its composition, thus allowing surgeons to choose IOLs more appropriate for different surgical situations and individual patient characteristics.

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“…Contact with intraocular lens (IOL) biomaterial causes LECs to undergo myofibroblastic changes and to produce extracellular matrix components [3][4][5]. Suggested risk factors for ACO and membrane growth include pseudoexfoliation syndrome, advanced age, diabetes mellitus, uveitis, myopia, pigmentary retinal degeneration, capsulorhexis size, and IOL design and material [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Capsular contraction syndrome following insertion of hydrophilic acrylic lens

2011

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A 52-year-old female of Asian Indian origin underwent uncomplicated phacoemulsification with insertion of a foldable hydrophilic acrylic single-piece intraocular lens which resulted in good postoperative vision. Five weeks later she presented with decreased vision and examination revealed fibrosis as well as phimosis of the anterior capsular opening. Surgical capsulotomy was performed as there was an extremely thick fibrotic membrane, thereby clearing the visual axis and improving her vision. Capsular contraction syndrome (CCS) is very rare following insertion of hydrophilic acrylic lenses. We describe a case of anterior capsular contraction syndrome following uneventful surgery and without any known predisposing factors.

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Cellular reaction on the anterior surface of 4 types of intraocular lenses

Cited by 56 publications

References 25 publications

Analysis of intraocular lens surface properties with atomic force microscopy

Analysis of intraocular lens surface properties with atomic force microscopy

Material Properties of Various Intraocular Lenses in an Experimental Study

Capsular contraction syndrome following insertion of hydrophilic acrylic lens

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