Cellular reactions in capillary and venous blood in northerners to a short‐term period in a climatic chamber

Abstract

The purpose is a comparative study of the cellular reactions in capillary and venous blood in northerners under general hypothermia in a climatic chamber during different photoperiods. The authors examined 108 relatively healthy people (80 women and 28 men aged 21-to 50-years old). Methods: The study included determining the hemogram, neutrograms, monocytograms, lymphocytograms, and phagocytic activity neutrophil granulocytes, enzyme immunoassay, flow cytometry, indirect immunoperoxidase, bioluminescence, systolic and diastolic blood pressure, and body temperature in the ear canal and on the skin of the rear left side of the right hand of volunteers before the effect of general cooling in the room at an air temperature and after 5 minutes of exposure to cold air. Results: It was established that total neutrophil count in venous blood was lower by 8.07% ± 0.41%, monocyte count by 51.32% ± 1.03%, and basophil count by 50.21% ± 1.24% than in capillary blood, but the lymphocyte count was higher by 25.23% ± 0.41% due to smaller forms that are known to be recirculating. After a 5-minute period in a climatic chamber at −25°C in 27.53% of individuals during a polar night and in 16.51% volunteers during a polar day had elevated levels of neutrophils in the venous blood due to the increase in the levels of tumor necrosis factor-α in blood and decrease in noradrenaline, adrenaline, and irisin. Conclusion: The systematic effect of general cooling, especially during the polar night, leads to a reduction in reserve adaptability with the formation of

Effect of climatic environment on immunological features of rheumatoid arthritis

“…Significant relationships have been reported regarding the number and percentage of CD4+, CD8+ T cells, CD20+ B cells, and ambient temperature, sunlight duration, and air pressure in healthy volunteers 30 . The systematic effect of general cooling by 5-min exposure to cold air at a temperature of − 25 °C in healthy volunteers leads to decrease of T-lymphocytes count in venous blood, which indicated their functional insufficiency 31 . Although it has been reported that environmental factors www.nature.com/scientificreports/ such as oxygen concentration 32,33 , acidification 34,35 , salt concentration 36 , and glucose, amino acid, and lipid metabolism [37][38][39] altered the differentiation and the function of immune cells, and contributed to the pathology of autoimmune diseases, it remains unclear how climatic factors such as air temperature and air pressure regulate immune cell function and the development of autoimmune diseases including RA.…”