Cellular redistribution of metabolites during glucagon and insulin control of gluconeogenesis in the isolated perfused rat liver

Parrilla, Roberto L.; Jimenez, Maria-Isabel; Ayuso-Parrilla, Matilde S.

doi:10.1016/0003-9861(76)90317-9

Cited by 36 publications

(9 citation statements)

References 40 publications

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“…1) (Arnal, Fauconneau et Pech, 1972). Le (Fulks, Li et Golberg, 1975 ;Bellemann et al, 1977), et diminution de la néoglucogenèse hépatique (Parilla, Jimenez et Ayuso-Parilla, 1976). Il complète les travaux de Grizard et al (1975) (Freychet, 1976a (Freychet, 1974) ; cette technique permet d'obtenir principalement de la monoiodoinsuline (activité spécifique égale à 80 ou 180 f-lCiffL9) avec une activité biologique identique à celle de l'insuline standard (Freychet, Roth et Neville, 1971).…”

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Influence de l'hyperinsulinémie sur les récepteurs d'insuline dans le foie du rat en croissance soumis à une restriction énergétique

Grizard¹,

Arnal²,

Pion³

et al. 1980

Reprod. Nutr. Dévelop.

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Influence de l'hyperinsulinémie sur les récepteurs d'insuline dans le foie du rat en croissance soumis à une restriction énergétique

Grizard¹,

Arnal²,

Pion³

et al. 1980

Reprod. Nutr. Dévelop.

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“…An inhibitory action on diphenylhydantoin, and zinc protamine glucagon. gluconeogenesis is also well established in animals (5,14,25).…”

Section: Discussionmentioning

confidence: 96%

“…An inhibitory action on diphenylhydantoin, and zinc protamine glucagon. gluconeogenesis is also well established in animals (5,14,25).A t 2 years of age the mental and motor development was Insulin deficiency in animals and man is associated with an moderately retarded. Physically, the patient was small (2.5 perincreased gluconeogenesis, which is normalized by insulin treat-centile), but with normal proportions.…”

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confidence: 98%

Reduced Gluconeogenesis due to Hyperinsulinism: Hormonal and Metabolic Studies in an Infant with Hypoglycemia

Vidnes¹,

Oyasater²

1978

Pediatr Res

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Summarygenesis in vivo in man, however, is still a matter of controversy ( 5 , 11). This paper presents evidence for a much reduced An infant with a of h~~o g l~c e m i a suffered from g l~c o n e~g e n~s i s in an infant with hyperinsulinism, The hypoglyh~~o g l~c e m i a caused h~~erinsulinism. G1ucagon se-cemia was best counteracted by injections of long acting glucacretion was normal. The in vivo incorporation of 14C from gon. alanine into glucose was much reduced, but the key gluconeogenic enzymes revealed normal to high activities in vitro, with normal intracellular distributions. The glucogenic amino acids in CASE REPORT plasma tended to be high, especially proline. A n alanine load revealed a normal glucagon secretion pattern, whereas the BRB, a boy, was born at term On February 16, l Y 7 j , after a insulin secretion was inappropriately strong. The insulin re-normal Pregnancy. Birthweight was 2800 g, length 48 cm, and sponse to glucagon, however, was subnormal. The alanine load the neonatal period was uneventful. b he ~a t i e n t has two sisters, caused a paradoxic drop in plasma pyruvate. Serial determina-One of whom suffered from hypoglycemia from the age of 2 tions of the fasting values of plasma alanine and free fatty acids months. the and the @FA) disclosed a highly significant negative correlation. had suffered from hypoglycemia. The sister and the mother The best therapeutic effect was obtained with long acting recovered s~ontaneously at 4-5 years of age, and are now in glucagon sc twice daily, but hypoglycemia before the next good health, except that the sister is slightly mentally retarded. injection of glucagon could not be avoided. Glucagon treatment Studies of the other members were refused. caused a marked drop in the plasma amino acids, including the The patient first experienced symptoms of hypoglycemia at branched-chained, and a highly significant decrease in plasma 4.5 months of age, when he got attacks with loss of tonus, eyetriglycerides and increase in FFA, whereas glycerol did not rolling, smacking of the lips, and, occasionally, convulsions. H e change. Dipheuylhydantoin caused a significant increase in Was first admitted to our hospital at 7 months of age, with a blood glucose, but therapeutic serum levels of the drug were glucose of 0.83 mmol/liter. Routine laboratory difficult to achieve. investigations were normal, except for moderate elevations of ~~~i~~ glucagon treatment an oral glucose tolerance test was alanine aminotransferase and aspartate aminotransferase in senormal, with a normal increase in insulin, whereas an iv glucose rum. These values later normalized, but intermittently alanine tolerance test was diabetic (KG = 1.0), and there was n o rise in aminotransferase, alkaline phosphatase, and y-glutam~l transinsulin.peptidase were elevated. The liver was not enlarged, and It is concluded that the reduced in viva incorporation of 1 4~ appeared normal by laparotomy for liver biopsy. ~i s t o l o~i c a l l~, into glucose from alanine reflected a reduced gluconeogenesis, ...

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“…Cela se traduit par une forte augmentation de la triglycéridémie (Toullec, Guilloteau et Coroller, 1979) (Grizard, Patureau-Mirand et PatureauMirand et al, 1976 (Fulks, Li et Golberg, 1975 ;Bellemann et al, 1977 ;Parilla, Jimenez et Ayuso-Parilla, 1976 ;Swendseid et al, 1967 (Guilloteau et al, 1975 Guilloteau et al (1975). En effet, l'aminoacidémie dépend de la vitesse d'évacuation gastrique, comme l'ont montré les expériences d'infusion duodénale des deux aliments (Guilloteau et al, 1981 (Kahn, 1980 (Bassett, 1974 ;Bloom et al, 1975 (Peret et Jacquot, 1972 ;Jarrousse et al, 1980 …”

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Influence de la cinétique d'évacuation gastrique de l'aliment sur l'insulinémie chez le veau préruminant

Grizard¹,

Toullec²,

Guilloteau³

et al. 1982

Reprod. Nutr. Dévelop.

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Summary. Effect of gastric emptying on plasma insulin in the preruminant calf.The aim of this work was to clarify the possible role of blood metabolites (glucose, aminoacids, triglycerides) in the regulation of postprandial blood insulin in the preruminant calf. The animals used were 6 male Friesian bull calves with an average weight of 80 kg. They were divided into groups I and li. During the first experimental period (A), group I received a control diet that contained skim-milk powder as the only protein source, whereas group 11 received an experimental diet containing fish protein concentrate as the main protein source. During the second experimental period (B), the diets were switched.It was previously shown that the rate of fat and amino acid absorption increased when milk proteins in such milk substitutes were replaced by hydrolyzed fish proteins (Guilloteau et al., 1975).The results showed that during any experimental period in the control group, there was a decrease in the postprandial blood free amino nitrogen. Blood triglycerides exhibited a small increase at 0.5 h after the meal but a large decrease at 1-4.5 h. The meal also resulted in a very large increase in blood glucose with maximal values occurring at 1-4.5 h. Blood insulin showed a large increment at 0.5 h then increased slowly, peaking at 2-3 h. The postprandial increase in blood insulin was less during the first experimental period than during the second one.In calves fed the fish diet, blood free amino nitrogen and blood triglycerides showed a large postprandial increase. Blood glucose exhibited a smaller postprandial increment than in the controls and began to decrease at half an hour. In contrast, the trend of changes in blood insulin was the same as in the controls (i.e. a maximum at 3 h occurring after a large increase at 0.5 h). There were no significant differences in blood insulin between the two experimental periods. It was lower in the calves fed the fish diet than in the controls during the first experimental period ; during the second period, it was similar in both groups. From these observations, it may be inferred that, as compared to the control diet, the fish diet resulted in a decrease in glucose stimulation of postprandial insulin secretion ; in contrast, the effect of aminoacids and lipids may be increased.Le remplacement des protéines du lait par des protéines de poisson dans l'aliment d'allaitement distribué au veau préruminant entraîne une accélération de l'évacuation gastrique des lipides, des protéines et parfois du lactose (Guilloteau

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Cellular redistribution of metabolites during glucagon and insulin control of gluconeogenesis in the isolated perfused rat liver

Cited by 36 publications

References 40 publications

Influence de l'hyperinsulinémie sur les récepteurs d'insuline dans le foie du rat en croissance soumis à une restriction énergétique

Influence de l'hyperinsulinémie sur les récepteurs d'insuline dans le foie du rat en croissance soumis à une restriction énergétique

Reduced Gluconeogenesis due to Hyperinsulinism: Hormonal and Metabolic Studies in an Infant with Hypoglycemia

Influence de la cinétique d'évacuation gastrique de l'aliment sur l'insulinémie chez le veau préruminant

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