Cellular Respiration

Zimmerman, Frederick J.; Arnim, Amélie von Saint André-von; McLaughlin, Jerry L.

doi:10.1016/b978-0-323-07307-3.10074-6

Cited by 34 publications

(31 citation statements)

References 187 publications

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“…The proton flux rate through the IV complex able to activate ATP synthase has been estimated as 3 × 10 21 protons per second coupled with an ATP synthesis rate of 9 × 10 20 molecules per seconds; to have an idea 65 kg ATP per day in resting conditions (ATP molecular mass is 507,18 g per mole), so the rate of GTP production could be at this extent and even more thinking about the metabolic engagement during sustained contraction (Zimmerman et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling

Pietrangelo

2021

Front. Pharmacol.

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Section: Introductionmentioning

confidence: 99%

Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling

Pietrangelo

2021

Front. Pharmacol.

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“…Nevertheless, this will not prevent the use of ATP-LW for the detection ATP in cells, since the concentration of ATP is around 1000-fold higher than ADP in cells. 3 We then determined that ATP-LW exhibits good stability over a pH range from 3-11 (Fig. S9 and S10).…”

Section: Resultsmentioning

confidence: 99%

“…[1][2] ATP concentrations range between 1 to 10 mM, with a 1000:1 ratio between ATP and adenosine diphosphate (ADP). 3 ATP aids the regulation of important cellular processes, which include cellular movement, 4 neurotransmission, 5 and ion channel function. 6 Thus, disruption to ATP homeostasis is linked to a number of diseases, including ischemia, Parkinson's disease and hypoglycaemia.…”

Section: Introductionmentioning

confidence: 99%

Dual-channel fluorescent probe for the simultaneous monitoring of peroxynitrite and adenosine-5’-triphosphate in cellular applications

Liu

Xue

et al. 2021

Preprint

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The concentrations of ATP and ONOO − have been correlated with the progression a number of diseases including ischemia-reperfusion injury and drug-induced liver injury. Here, we report the development of fluorescent probe, ATP-LW, which enables the simultaneous detection of ONOO − and ATP. ONOO − selectively oxidises the boronate pinacol ester of ATP-LW, to afford the fluorescent 4-hydroxy-1,8naphthalimide product NA-OH (λex = 450 nm, λem = 562 nm or λex = 488 nm, λem = 568 nm). While, the binding of ATP to ATP-LW induces the spirolactam ring opening of rhodamine to afford a highly emissive product (λex = 520 nm, λem = 587 nm). Due to the differences in emission between the ONOO − and ATP products, ATP-LW exhibits the unique ability to image ONOO − levels in the green channel (λex = 488 nm, λem = 500-575 nm) and ATP concentrations using the red channel (λex = 514 nm, λem = 575-650 nm). This was demonstrated using hepatocytes (HL-7702 cells) in cellular imaging experiments. The treatment of HL-7702 cell line with oligomycin A (an inhibitor of ATP synthase) resulted in a reduction of ATP in the red channel and increase in ONOO − green channel. While, the presence of SIN-1 (an exogenous ONOO − donor) results in an increase of ONOO − , and decrease in ATP. Significantly, when HL-7702 cells were treated with acetaminophen as a biological model for drug-induced liver injury, an increase in ONOO − green and decrease in ATP red channel fluorescence was observed. These results illustrate the utility of ATP-LW as a chemical tool to simultaneously monitor ATP and ONOO − concentrations in cellular-based applications.

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“…The energy utilized every day by an adult requires the hydrolysis of 100 to 150 Moles of ATP. This implies every ATP molecule must be reused 1000 or more multiple times in a day [3]. ATP cannot be stored and so its synthesis is closely linked to its consumption.…”

Section: Atp: the Fuel For Lifementioning

confidence: 99%

ATP Synthase: Structure, Function and Inhibition

Neupane

Bhuju

Thapa

et al. 2019

Biomolecular Concepts

146

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Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Since ATP is the major energy currency in all living cells, its synthesis and function have widely been studied over the last few decades uncovering several aspects of ATP synthase. This review intends to summarize the structure, function and inhibition of the ATP synthase.

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Cellular Respiration

Cited by 34 publications

References 187 publications

Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling

Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling

Dual-channel fluorescent probe for the simultaneous monitoring of peroxynitrite and adenosine-5’-triphosphate in cellular applications

ATP Synthase: Structure, Function and Inhibition

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