1995
DOI: 10.1152/ajplung.1995.269.6.l800
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Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice

Abstract: Clara cells, progenitors for bronchiolar epithelium, are also primary targets for metabolically activated pulmonary cytotoxicants and have an abundance of the cytochrome P-450 monooxygenases required for xenobiotic metabolism. To define the repair pattern after massive Clara cell injury, mice were treated with naphthalene, and lungs evaluated 1-14 days postinjury (DPI). Clara cells of terminal bronchioles were vacuolated and swollen 1 DPI, exfoliated 2 DPI, and resembled controls at 14 DPI. The volume fraction… Show more

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Cited by 120 publications
(144 citation statements)
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“…It has previously been shown that peribronchiolar interstitial cells can proliferate in response to naphthalene-induced Clara cell damage in mice. 11,12 These proliferating interstitial cells are believed to be alveolar macrophages and fibroblast-like cells, and have been reported to interact with the basal lamina of adjacent bronchiolar epithelial cells during the repair process. 11,12 Interestingly, delayed airway epithelial repair can promote fibroblast proliferation and fibrosis in other models of lung injury.…”
Section: Discussionmentioning
confidence: 99%
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“…It has previously been shown that peribronchiolar interstitial cells can proliferate in response to naphthalene-induced Clara cell damage in mice. 11,12 These proliferating interstitial cells are believed to be alveolar macrophages and fibroblast-like cells, and have been reported to interact with the basal lamina of adjacent bronchiolar epithelial cells during the repair process. 11,12 Interestingly, delayed airway epithelial repair can promote fibroblast proliferation and fibrosis in other models of lung injury.…”
Section: Discussionmentioning
confidence: 99%
“…11,12 These proliferating interstitial cells are believed to be alveolar macrophages and fibroblast-like cells, and have been reported to interact with the basal lamina of adjacent bronchiolar epithelial cells during the repair process. 11,12 Interestingly, delayed airway epithelial repair can promote fibroblast proliferation and fibrosis in other models of lung injury. 45,46 In our study, histological analysis of Masson's trichrome staining did not show any evidence of pulmonary fibrosis in the lungs of both Elf3 þ / þ and Elf3À/À mice after naphthalene exposure (data not shown).…”
Section: Discussionmentioning
confidence: 99%
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“…The cytotoxicant naphthalene and its derivatives have been widely used to study acute injury mechanisms and to identify stem/progenitor populations in rodent airways [13][14][15]. Few studies however have used these models to identify the growth factor signals that drive airway regeneration following injury.…”
Section: Characterisation Of Regeneration Process In Rat Airways Follmentioning
confidence: 99%
“…13 The best characterized is naphthalene (NA), a Clara cell-specific cytotoxicant. 14 Clara cells are located on the bronchial epithelium 15,16 and are responsible for the secretion of various products into the bronchial lining that are important for the protection of the epithelium (such as surfactant proteins) 15,17 as well as inhibiting inflammatory reactions mediated via the Th2 response. 15,17 Our hypothesis was that superimposing the NA-induced model of epithelial damage onto the gold standard chronic OVA-induced model of AAD would exhibit a wider spectrum of features that were associated with asthma (ie, AI, airway epithelial damage, airway fibrosis, and AHR) and that may be used in the future as a better representative experimental model of human asthma.…”
mentioning
confidence: 99%